@inproceedings{363ce09184094e4691dace083cf0da6e,
title = "Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage",
abstract = "We reported previously that Notch signaling is activated in human arteriovenous malformations (AVMs) and that intracerebral hemorrhage (ICH) in humans is accompanied by increased neurogenesis. The former phenomenon may be involved in AVM pathogenesis and the latter in the brain's response to ICH-induced injury. Here we describe increased expression of the hypoxia-inducible neuroprotective protein, neuroglobin (Ngb), in neurons surrounding unruptured AVMs and in the perihematomal region adjacent to ICH. In these disorders, as in other clinical settings, such as ischemic stroke, AVM-and ICH-induced overexpression of Ngb may be stimulated by ischemic hypoxia and may help to constrain brain injury.",
keywords = "Arteriovenous malformation, Hypoxia, Intracerebral hemorrhage, Ischemia, Neuroglobin",
author = "Kunlin Jin and Xiaoou Mao and Lin Xie and Greenberg, {David A.}",
note = "Funding Information: Acknowledgments Supported by USPHS grant NS62040 to David A. Greenberg. Conflict of interest statement ",
year = "2011",
doi = "10.1007/978-3-7091-0693-8_52",
language = "English",
isbn = "9783709106921",
series = "Acta Neurochirurgica, Supplementum",
publisher = "Springer-Verlag Wien",
number = "111",
pages = "315--319",
booktitle = "Intracerebral Hemorrhage Research",
edition = "111",
}