Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage

Kunlin Jin, Xiaoou Mao, Lin Xie, David A. Greenberg

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Scopus citations


We reported previously that Notch signaling is activated in human arteriovenous malformations (AVMs) and that intracerebral hemorrhage (ICH) in humans is accompanied by increased neurogenesis. The former phenomenon may be involved in AVM pathogenesis and the latter in the brain's response to ICH-induced injury. Here we describe increased expression of the hypoxia-inducible neuroprotective protein, neuroglobin (Ngb), in neurons surrounding unruptured AVMs and in the perihematomal region adjacent to ICH. In these disorders, as in other clinical settings, such as ischemic stroke, AVM-and ICH-induced overexpression of Ngb may be stimulated by ischemic hypoxia and may help to constrain brain injury.

Original languageEnglish
Title of host publicationIntracerebral Hemorrhage Research
Subtitle of host publicationFrom Bench to Bedside
PublisherSpringer-Verlag Wien
Number of pages5
ISBN (Print)9783709106921
StatePublished - 2011

Publication series

NameActa Neurochirurgica, Supplementum
ISSN (Print)0065-1419
ISSN (Electronic)0001-6268


  • Arteriovenous malformation
  • Hypoxia
  • Intracerebral hemorrhage
  • Ischemia
  • Neuroglobin


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