TY - JOUR
T1 - Neuroglobin
T2 - an endogenous neuroprotectant
AU - Greenberg, David A.
AU - Jin, Kunlin
AU - Khan, Adil A.
N1 - Funding Information:
This work was supported by NIH grant NS35965 and by the Buck Institute for Age Research.
PY - 2008/2
Y1 - 2008/2
N2 - Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain neurons, and appears to modulate hypoxic-ischemic brain injury. Evidence includes the observations that neuronal hypoxia and cerebral ischemia induce Ngb expression, that enhancing Ngb expression reduces - and knocking down Ngb expression increases - hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction. However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear.
AB - Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain neurons, and appears to modulate hypoxic-ischemic brain injury. Evidence includes the observations that neuronal hypoxia and cerebral ischemia induce Ngb expression, that enhancing Ngb expression reduces - and knocking down Ngb expression increases - hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction. However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear.
UR - http://www.scopus.com/inward/record.url?scp=38649090098&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2007.09.003
DO - 10.1016/j.coph.2007.09.003
M3 - Review article
C2 - 17942367
AN - SCOPUS:38649090098
VL - 8
SP - 20
EP - 24
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
IS - 1
ER -