Neuroglobin: an endogenous neuroprotectant

David A. Greenberg, Kunlin Jin, Adil A. Khan

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain neurons, and appears to modulate hypoxic-ischemic brain injury. Evidence includes the observations that neuronal hypoxia and cerebral ischemia induce Ngb expression, that enhancing Ngb expression reduces - and knocking down Ngb expression increases - hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction. However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalCurrent Opinion in Pharmacology
Issue number1
StatePublished - Feb 2008


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