Neurogenesis in the aging brain.

Veronica Galvan, Kunlin Jin

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to maintain the functional stability of adult brain circuitry. However, recent studies have demonstrated that neurogenesis does indeed continue into and throughout adult life in discrete regions of the central nervous systems (CNS) of all mammals, including humans. Although neurogenesis may contribute to the ability of the adult brain to function normally and be induced in response to cerebral diseases for self-repair, this nevertheless declines with advancing age. Understanding the basic biology of neural stem cells and the molecular and cellular regulation mechanisms of neurogenesis in young and aged brain will allow us to modulate cell replacement processes in the adult brain for the maintenance of healthy brain tissues and for repair of disease states in the elderly.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalClinical interventions in aging
Volume2
Issue number4
StatePublished - 2007

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Neurogenesis
Brain
Neural Stem Cells
Nervous System
Mammals
Central Nervous System
Maintenance
Parturition
Population

Cite this

Galvan, Veronica ; Jin, Kunlin. / Neurogenesis in the aging brain. In: Clinical interventions in aging. 2007 ; Vol. 2, No. 4. pp. 605-610.
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Galvan, V & Jin, K 2007, 'Neurogenesis in the aging brain.', Clinical interventions in aging, vol. 2, no. 4, pp. 605-610.

Neurogenesis in the aging brain. / Galvan, Veronica; Jin, Kunlin.

In: Clinical interventions in aging, Vol. 2, No. 4, 2007, p. 605-610.

Research output: Contribution to journalReview article

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