Neurogenesis in adult human brain after traumatic brain injury

Weiming Zheng, Qichuan Zhuge, Ming Zhong, Gourong Chen, Bei Shao, Hong Wang, Xiaoou Mao, Lin Xie, Kunlin Jin

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


While much work has been conducted regarding the neurogenesis response to traumatic brain injury (TBI) in rodents, it remains largely unknown whether neurogenesis in adult human brain also responds to TBI in a similar manner. Here, we performed immunocytochemistry on 11 brain specimens from patients with traumatic brain injury, who underwent surgical intervention. We found that expression of neural stem/progenitor cell (NSC) protein markers, including DCX, TUC4, PSA-NCAM, SOX2 and NeuroD, was increased in the perilesional cortex of human brain after TBI compared to that of normal brain. Confocal images showed that these NSC proteins were expressed in one single cell. We also found that proliferative markers were expressed in NSC protein-positive cells after TBI, and the number of proliferative NSCs was significantly increased after TBI. Our data suggest that TBI may also induce neurogenesis in human brain.

Original languageEnglish
Pages (from-to)1872-1880
Number of pages9
JournalJournal of Neurotrauma
Issue number22
StatePublished - 15 Nov 2013


  • brain trauma
  • human
  • injury
  • neurogenesis
  • stem cells


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