Neurogenesis associated with endothelin-induced cortical infarction in the mouse

Yaoming Wang, Kunlin Jin, David A. Greenberg

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We investigated the effect of small cortical ischemic lesions, produced by intracerebral injection of the vasoconstrictor endothelin-1, on neurogenesis in the adult mouse subventricular zone. Endothelin-1 (0.5-1 μg) produced infarcts restricted to the cortex, and associated neurobehavioral deficits that largely resolved by 3 days. Bromodeoxyuridine labeling of proliferating cells in the subventricular zone was elevated by about 50% in endothelin-1-treated mice, and cells reactive for doublecortin, a marker for immature neurons, were similarly increased in number. These findings indicate that small ischemic lesions restricted to adult cerebral cortex can stimulate neuroproliferation at a distance.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalBrain Research
Issue number1
StatePublished - 5 Sep 2007


  • Doublecortin
  • Endothelin
  • Ischemia
  • Neurogenesis
  • Stroke
  • Subventricular zone


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