Abstract
We investigated the effect of small cortical ischemic lesions, produced by intracerebral injection of the vasoconstrictor endothelin-1, on neurogenesis in the adult mouse subventricular zone. Endothelin-1 (0.5-1 μg) produced infarcts restricted to the cortex, and associated neurobehavioral deficits that largely resolved by 3 days. Bromodeoxyuridine labeling of proliferating cells in the subventricular zone was elevated by about 50% in endothelin-1-treated mice, and cells reactive for doublecortin, a marker for immature neurons, were similarly increased in number. These findings indicate that small ischemic lesions restricted to adult cerebral cortex can stimulate neuroproliferation at a distance.
Original language | English |
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Pages (from-to) | 118-122 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 1167 |
Issue number | 1 |
DOIs | |
State | Published - 5 Sep 2007 |
Keywords
- Doublecortin
- Endothelin
- Ischemia
- Neurogenesis
- Stroke
- Subventricular zone