Neurogenesis after primary intracerebral hemorrhage in adult human brain

Jianfeng Shen, Lin Xie, Xia Oou Mao, Yongqing Zhou, Renya Zhan, David A. Greenberg, Kunlin Jin

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Neurogenesis occurs in discrete regions of normal brains of adult mammals including humans, and is induced in response to brain injury and neurodegenerative disease. Whether intracerebral hemorrhage can also induce neurogenesis in human brain is unknown. Specimens were obtained from patients with primary intracerebral hemorrhage undergoing surgical evacuation of an intracerebral hematoma, and evaluated by two-photon laser scanning confocal microscopy. We found that neural stem/progenitor cell-specific protein markers were expressed in cells located in the perihematomal regions of the basal ganglia and parietal lobe of the adult human brain after primary intracerebral hemorrhage (n=5). Cells in this region also expressed cell proliferation markers, which colocalized to the same cells that expressed neural stem/progenitor cell-specific proteins. Our data suggest that intracerebral hemorrhage induces neurogenesis in the adult human brain.

Original languageEnglish
Pages (from-to)1460-1468
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume28
Issue number8
DOIs
StatePublished - Aug 2008

Keywords

  • Brain
  • Human
  • Intracerebral hemorrhage
  • Neural stem cells
  • Neurogenesis

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