TY - JOUR
T1 - Neurodegeneration and neurogenesis
T2 - Focus on Alzheimer's disease
AU - Greenberg, David A.
AU - Jin, Kunlin
PY - 2006/2
Y1 - 2006/2
N2 - Neurogenesis, or the production of new neurons from neuronal precursor cells, is a normal phenomenon in the adult brain, and is accentuated by brain injury. Forms of injury associated with increased neurogenesis include both acute (e.g., stroke) and chronic neurodegenerations. Studies on human postmortem material and transgenic mice overexpressing amyloid precursor protein mutations found in familial Alzheimer's disease (AD) suggest that AD is associated with enhanced neurogenesis. However, the mechanism responsible for this effect is unknown, as is what influence it may have on the clinical course of murine or human AD. If AD leads to the production of fully functional, mature neurons that can restore brain function, strategies aimed at further increasing endogenous neurogenesis may have therapeutic value.
AB - Neurogenesis, or the production of new neurons from neuronal precursor cells, is a normal phenomenon in the adult brain, and is accentuated by brain injury. Forms of injury associated with increased neurogenesis include both acute (e.g., stroke) and chronic neurodegenerations. Studies on human postmortem material and transgenic mice overexpressing amyloid precursor protein mutations found in familial Alzheimer's disease (AD) suggest that AD is associated with enhanced neurogenesis. However, the mechanism responsible for this effect is unknown, as is what influence it may have on the clinical course of murine or human AD. If AD leads to the production of fully functional, mature neurons that can restore brain function, strategies aimed at further increasing endogenous neurogenesis may have therapeutic value.
KW - Dentate gyrus
KW - Hippocampus
KW - Neurodegeneration
KW - Neurogenesis
KW - Neuronal precursor cells
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=33645882245&partnerID=8YFLogxK
U2 - 10.2174/156720506775697106
DO - 10.2174/156720506775697106
M3 - Article
C2 - 16472199
AN - SCOPUS:33645882245
SN - 1567-2050
VL - 3
SP - 25
EP - 28
JO - Current Alzheimer Research
JF - Current Alzheimer Research
IS - 1
ER -