Network Control Mechanisms-Cellular Milieu

Victor V. Uteshev-Gaard; Alexander G. Gusev; Evgeny A. Sametsky

doi:10.1016/B978-0-12-415804-7.00010-1

Network Control Mechanisms-Cellular Milieu

Victor V. Uteshev-Gaard, Alexander G. Gusev, Evgeny A. Sametsky

Pharmacology & Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

The brain is a highly effective integrator and processor of sensory-motor signaling, which results from the synergistic and coordinated actions of neurons, glial cells, and the external milieu. Brain neurons form functional networks and communicate via chemical and electrical synapses, as well as diffusion (or volume) transmission and ephaptic transmission. Therefore, the external milieu supports both neuronal function and interneuronal communication. This chapter discusses the role of the external milieu in determining the effectiveness of neuronal networks. Various biophysical properties of the external milieu contribute to the effectiveness of neuronal network operation, including the presence of specific neuroactive compounds and ions in the extracellular fluid, the level of oxygen, the brain temperature, neuronal and glial communication, and the spatiotemporal distribution of inputs.

Original language	English
Title of host publication	Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics
Publisher	Elsevier Inc.
Pages	135-144
Number of pages	10
ISBN (Print)	9780124158047
DOIs	https://doi.org/10.1016/B978-0-12-415804-7.00010-1
State	Published - 1 Jan 2014

Keywords

Ex vivo
Extracellular space
Ion channels
Ion diffusion
Ionic homeostasis
Ischemia
Neuronal network
Seizure
Spreading depression

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10.1016/B978-0-12-415804-7.00010-1

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AU - Gusev, Alexander G.

AU - Sametsky, Evgeny A.

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KW - Extracellular space

KW - Ion channels

KW - Ion diffusion

KW - Ionic homeostasis

KW - Ischemia

KW - Neuronal network

KW - Seizure

KW - Spreading depression

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BT - Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics

PB - Elsevier Inc.

ER -

Network Control Mechanisms-Cellular Milieu

Abstract

Keywords

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