Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

Xin Chen, Wenhao Chen, Guangying Chen, Changri Han, Johnny Jianglin He, Xueming Zhou, Zhangxin Yu, Chunyan Dai, Xiaoping Song

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalPhytochemistry
Volume145
DOIs
StatePublished - 1 Jan 2018

Fingerprint

Scutellaria
Clerodane Diterpenes
Stereochemistry
Diterpenes
stereochemistry
petroleum
diterpenoids
X-ray diffraction
crystals
ethers
Nuclear magnetic resonance
HIV
Single crystals
X ray diffraction
X-Ray Diffraction
Experiments
antiretroviral properties
naphtha

Keywords

  • HIV lytic replication
  • Labiatae
  • Neo-clerodane diterpenoids
  • Scutellaria formosana

Cite this

Chen, Xin ; Chen, Wenhao ; Chen, Guangying ; Han, Changri ; He, Johnny Jianglin ; Zhou, Xueming ; Yu, Zhangxin ; Dai, Chunyan ; Song, Xiaoping. / Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana. In: Phytochemistry. 2018 ; Vol. 145. pp. 1-9.
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title = "Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana",
abstract = "Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL.",
keywords = "HIV lytic replication, Labiatae, Neo-clerodane diterpenoids, Scutellaria formosana",
author = "Xin Chen and Wenhao Chen and Guangying Chen and Changri Han and He, {Johnny Jianglin} and Xueming Zhou and Zhangxin Yu and Chunyan Dai and Xiaoping Song",
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Chen, X, Chen, W, Chen, G, Han, C, He, JJ, Zhou, X, Yu, Z, Dai, C & Song, X 2018, 'Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana', Phytochemistry, vol. 145, pp. 1-9. https://doi.org/10.1016/j.phytochem.2017.09.002

Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana. / Chen, Xin; Chen, Wenhao; Chen, Guangying; Han, Changri; He, Johnny Jianglin; Zhou, Xueming; Yu, Zhangxin; Dai, Chunyan; Song, Xiaoping.

In: Phytochemistry, Vol. 145, 01.01.2018, p. 1-9.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

AU - Chen, Xin

AU - Chen, Wenhao

AU - Chen, Guangying

AU - Han, Changri

AU - He, Johnny Jianglin

AU - Zhou, Xueming

AU - Yu, Zhangxin

AU - Dai, Chunyan

AU - Song, Xiaoping

PY - 2018/1/1

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N2 - Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL.

AB - Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL.

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