TY - JOUR
T1 - Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana
AU - Chen, Xin
AU - Chen, Wenhao
AU - Chen, Guangying
AU - Han, Changri
AU - He, Johnny J.
AU - Zhou, Xueming
AU - Yu, Zhangxin
AU - Dai, Chunyan
AU - Song, Xiaoping
N1 - Funding Information:
The work was financially supported by the State of International Science and Technology Cooperation Special ( 2014DFA40850 ), the National Natural Science Foundation of China (Nos. 81360478 , 21202030 , 21362009 , 21662012 ), Program for Innovative Research Team in University ( IRT-16R19 ), and the Hainan Province Natural Science Foundation of Innovatie Research Team Project ( 2016CXTD007 ).
Publisher Copyright:
© 2017
PY - 2018/1
Y1 - 2018/1
N2 - Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL.
AB - Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL.
KW - HIV lytic replication
KW - Labiatae
KW - Neo-clerodane diterpenoids
KW - Scutellaria formosana
UR - http://www.scopus.com/inward/record.url?scp=85037657115&partnerID=8YFLogxK
U2 - 10.1016/j.phytochem.2017.09.002
DO - 10.1016/j.phytochem.2017.09.002
M3 - Article
C2 - 29031114
AN - SCOPUS:85037657115
SN - 0031-9422
VL - 145
SP - 1
EP - 9
JO - Phytochemistry
JF - Phytochemistry
ER -