Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1

Jizhong Zhang, Geling Li, Andre Bafica, Milica Pantelic, Pei Zhang, Hal Broxmeyer, Ying Liu, Lee Wetzler, Johnny J. He, Tie Chen

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Abstract

Clinical studies indicate that Neisseria gonorrhoeae (gonococci (GC)) has the capacity to enhance HIV type 1 (HIV-1) infection. We studied whether GC enhances HIV infection of activated dendritic cells (DCs). The results show that GC can dramatically enhance HIV replication in human DCs during coinfection. The GC component responsible for HIV infection enhancement may be peptidoglycan, which activates TLR2. TLR2 involvement is suggested by bacterial lipoprotein, a TLR2-specific inducer, which stimulates a strong enhancement of HIV infection by human DCs. Moreover, participation of TLR2 is further implicated because GC is unable to stimulate expression of HIV in DCs of TLR2-deficient HIV-1-transgenic mice. These results provide one potential mechanism through which GC infection increases HIV replication in patients infected with both GC and HIV.

Original languageEnglish
Pages (from-to)7995-8002
Number of pages8
JournalJournal of Immunology
Volume174
Issue number12
DOIs
StatePublished - 15 Jun 2005

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    Zhang, J., Li, G., Bafica, A., Pantelic, M., Zhang, P., Broxmeyer, H., Liu, Y., Wetzler, L., He, J. J., & Chen, T. (2005). Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1. Journal of Immunology, 174(12), 7995-8002. https://doi.org/10.4049/jimmunol.174.12.7995