Needle-implantable, wireless biosensor for continuous glucose monitoring

Santhisagar Vaddiraju, Michail Kastellorizios, Allen Legassey, Diane Burgess, Faquir Jain, Fotios Papadimitrakopoulos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Unlike non-invasive and minimally invasive continuous monitoring of glucose (CGM) devices, invasive devices require less rigorous calibration and exhibit smaller subject-to-subject variability. Biorasis, Inc. and the University of Connecticut are developing a totally implantable CGM device. Glucowizzard™ is engineered at the smallest possible footprint (0.5 × 0.5 × 5 mm). This miniaturization is made possible by utilizing light both for powering and wireless communication. In addition, Glucowizzard™ utilizes 'smart' hydrogel coatings intended for localized release of various tissue response modifiers for effective control of negative tissue responses. The use of light-based powering and communication together with advanced microelectronic design rules has allowed the fabrication of truly miniaturized CGM device. The drug delivery coating has enabled substantial reduction of negative tissue responses for up to 1 month in small as well as large animals (rats and minipigs). The functionality of Glucowizzard™ has been demonstrated in vivo in both rats and minipigs.

Original languageEnglish
Title of host publication2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781467372015
DOIs
StatePublished - 15 Oct 2015
Event12th IEEE International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015 - Cambridge, United States
Duration: 9 Jun 201512 Jun 2015

Publication series

Name2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015

Other

Other12th IEEE International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015
CountryUnited States
CityCambridge
Period9/06/1512/06/15

Keywords

  • biodegradable microspheres
  • biofouling
  • hydrogels
  • implantable glucose sensors
  • macroscopic porosity
  • negative tissue response
  • outer coatings
  • permeability
  • sensor sensitivity

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  • Cite this

    Vaddiraju, S., Kastellorizios, M., Legassey, A., Burgess, D., Jain, F., & Papadimitrakopoulos, F. (2015). Needle-implantable, wireless biosensor for continuous glucose monitoring. In 2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015 [7299421] (2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BSN.2015.7299421