TY - GEN
T1 - Needle-implantable, wireless biosensor for continuous glucose monitoring
AU - Vaddiraju, Santhisagar
AU - Kastellorizios, Michail
AU - Legassey, Allen
AU - Burgess, Diane
AU - Jain, Faquir
AU - Papadimitrakopoulos, Fotios
PY - 2015/10/15
Y1 - 2015/10/15
N2 - Unlike non-invasive and minimally invasive continuous monitoring of glucose (CGM) devices, invasive devices require less rigorous calibration and exhibit smaller subject-to-subject variability. Biorasis, Inc. and the University of Connecticut are developing a totally implantable CGM device. Glucowizzard™ is engineered at the smallest possible footprint (0.5 × 0.5 × 5 mm). This miniaturization is made possible by utilizing light both for powering and wireless communication. In addition, Glucowizzard™ utilizes 'smart' hydrogel coatings intended for localized release of various tissue response modifiers for effective control of negative tissue responses. The use of light-based powering and communication together with advanced microelectronic design rules has allowed the fabrication of truly miniaturized CGM device. The drug delivery coating has enabled substantial reduction of negative tissue responses for up to 1 month in small as well as large animals (rats and minipigs). The functionality of Glucowizzard™ has been demonstrated in vivo in both rats and minipigs.
AB - Unlike non-invasive and minimally invasive continuous monitoring of glucose (CGM) devices, invasive devices require less rigorous calibration and exhibit smaller subject-to-subject variability. Biorasis, Inc. and the University of Connecticut are developing a totally implantable CGM device. Glucowizzard™ is engineered at the smallest possible footprint (0.5 × 0.5 × 5 mm). This miniaturization is made possible by utilizing light both for powering and wireless communication. In addition, Glucowizzard™ utilizes 'smart' hydrogel coatings intended for localized release of various tissue response modifiers for effective control of negative tissue responses. The use of light-based powering and communication together with advanced microelectronic design rules has allowed the fabrication of truly miniaturized CGM device. The drug delivery coating has enabled substantial reduction of negative tissue responses for up to 1 month in small as well as large animals (rats and minipigs). The functionality of Glucowizzard™ has been demonstrated in vivo in both rats and minipigs.
KW - biodegradable microspheres
KW - biofouling
KW - hydrogels
KW - implantable glucose sensors
KW - macroscopic porosity
KW - negative tissue response
KW - outer coatings
KW - permeability
KW - sensor sensitivity
UR - http://www.scopus.com/inward/record.url?scp=84961656299&partnerID=8YFLogxK
U2 - 10.1109/BSN.2015.7299421
DO - 10.1109/BSN.2015.7299421
M3 - Conference contribution
AN - SCOPUS:84961656299
T3 - 2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015
BT - 2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 9 June 2015 through 12 June 2015
ER -