Near-haploid acute lymphoblastic leukemia: A unique subgroup with a poor prognosis?

G. M. Brodeur, D. L. Williams, A. T. Look, W. P. Bowman, D. K. Kalwinsky

Research output: Contribution to journalArticle

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Abstract

We describe two adolescent girls with acute lymphoblastic leukemia (ALL) whose leukemia cells were near-haploid. Their lymphoblasts stained in a block pattern with periodic acid Schiff and had 'common ALL' surface markers confirmed by indirect immunofluorescence. Each patient had two populations of blasts, one near-haploid and one hyperdiploid, which was an exact doubling of the near-haploid karyotype. The first patient had a predominant population of cells with 26 chromosomes and a few with 52, while the second had a predominance of cells with 56 and a minority with 28. Flow cytometric analysis of DNA content initially detected the minor near-haploid population in the second patient, which was confirmed later by cytogenetic review of the marrow sample. In addition to our two patients, only four patients have been reported with near-haploid ALL. Of these six, five were girls, five were adolescents, and five had short survivals (median, 10 mo). All six had disomy for chromosome 21 with or without disomy for chromosomes 10, 14, 18, or X (four patients each). Thus, near-haploid ALL may represent a unique subgroup of ALL with a poor prognosis. To detect these and other possible subgroups, we have included cytogenetic analysis and flow cytometric analysis of DNA content in our initial evaluation of patients with ALL.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalBlood
Volume58
Issue number1
StatePublished - 17 Aug 1981

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Haploidy
Chromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Periodic Acid
DNA
Cells
Population
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 10
Polyploidy
Cytogenetic Analysis
Indirect Fluorescent Antibody Technique
Karyotype
Cytogenetics
Leukemia
Bone Marrow
Survival

Cite this

Brodeur, G. M., Williams, D. L., Look, A. T., Bowman, W. P., & Kalwinsky, D. K. (1981). Near-haploid acute lymphoblastic leukemia: A unique subgroup with a poor prognosis? Blood, 58(1), 14-19.
Brodeur, G. M. ; Williams, D. L. ; Look, A. T. ; Bowman, W. P. ; Kalwinsky, D. K. / Near-haploid acute lymphoblastic leukemia : A unique subgroup with a poor prognosis?. In: Blood. 1981 ; Vol. 58, No. 1. pp. 14-19.
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abstract = "We describe two adolescent girls with acute lymphoblastic leukemia (ALL) whose leukemia cells were near-haploid. Their lymphoblasts stained in a block pattern with periodic acid Schiff and had 'common ALL' surface markers confirmed by indirect immunofluorescence. Each patient had two populations of blasts, one near-haploid and one hyperdiploid, which was an exact doubling of the near-haploid karyotype. The first patient had a predominant population of cells with 26 chromosomes and a few with 52, while the second had a predominance of cells with 56 and a minority with 28. Flow cytometric analysis of DNA content initially detected the minor near-haploid population in the second patient, which was confirmed later by cytogenetic review of the marrow sample. In addition to our two patients, only four patients have been reported with near-haploid ALL. Of these six, five were girls, five were adolescents, and five had short survivals (median, 10 mo). All six had disomy for chromosome 21 with or without disomy for chromosomes 10, 14, 18, or X (four patients each). Thus, near-haploid ALL may represent a unique subgroup of ALL with a poor prognosis. To detect these and other possible subgroups, we have included cytogenetic analysis and flow cytometric analysis of DNA content in our initial evaluation of patients with ALL.",
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Brodeur, GM, Williams, DL, Look, AT, Bowman, WP & Kalwinsky, DK 1981, 'Near-haploid acute lymphoblastic leukemia: A unique subgroup with a poor prognosis?', Blood, vol. 58, no. 1, pp. 14-19.

Near-haploid acute lymphoblastic leukemia : A unique subgroup with a poor prognosis? / Brodeur, G. M.; Williams, D. L.; Look, A. T.; Bowman, W. P.; Kalwinsky, D. K.

In: Blood, Vol. 58, No. 1, 17.08.1981, p. 14-19.

Research output: Contribution to journalArticle

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N2 - We describe two adolescent girls with acute lymphoblastic leukemia (ALL) whose leukemia cells were near-haploid. Their lymphoblasts stained in a block pattern with periodic acid Schiff and had 'common ALL' surface markers confirmed by indirect immunofluorescence. Each patient had two populations of blasts, one near-haploid and one hyperdiploid, which was an exact doubling of the near-haploid karyotype. The first patient had a predominant population of cells with 26 chromosomes and a few with 52, while the second had a predominance of cells with 56 and a minority with 28. Flow cytometric analysis of DNA content initially detected the minor near-haploid population in the second patient, which was confirmed later by cytogenetic review of the marrow sample. In addition to our two patients, only four patients have been reported with near-haploid ALL. Of these six, five were girls, five were adolescents, and five had short survivals (median, 10 mo). All six had disomy for chromosome 21 with or without disomy for chromosomes 10, 14, 18, or X (four patients each). Thus, near-haploid ALL may represent a unique subgroup of ALL with a poor prognosis. To detect these and other possible subgroups, we have included cytogenetic analysis and flow cytometric analysis of DNA content in our initial evaluation of patients with ALL.

AB - We describe two adolescent girls with acute lymphoblastic leukemia (ALL) whose leukemia cells were near-haploid. Their lymphoblasts stained in a block pattern with periodic acid Schiff and had 'common ALL' surface markers confirmed by indirect immunofluorescence. Each patient had two populations of blasts, one near-haploid and one hyperdiploid, which was an exact doubling of the near-haploid karyotype. The first patient had a predominant population of cells with 26 chromosomes and a few with 52, while the second had a predominance of cells with 56 and a minority with 28. Flow cytometric analysis of DNA content initially detected the minor near-haploid population in the second patient, which was confirmed later by cytogenetic review of the marrow sample. In addition to our two patients, only four patients have been reported with near-haploid ALL. Of these six, five were girls, five were adolescents, and five had short survivals (median, 10 mo). All six had disomy for chromosome 21 with or without disomy for chromosomes 10, 14, 18, or X (four patients each). Thus, near-haploid ALL may represent a unique subgroup of ALL with a poor prognosis. To detect these and other possible subgroups, we have included cytogenetic analysis and flow cytometric analysis of DNA content in our initial evaluation of patients with ALL.

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Brodeur GM, Williams DL, Look AT, Bowman WP, Kalwinsky DK. Near-haploid acute lymphoblastic leukemia: A unique subgroup with a poor prognosis? Blood. 1981 Aug 17;58(1):14-19.