TY - JOUR
T1 - Navajo, Pueblo, and Sioux population data on the loci HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80
AU - Scholl, Susan
AU - Budowle, Bruce
AU - Radecki, Kristin
AU - Salvo, Mark
PY - 1996
Y1 - 1996
N2 - Navajo, Pueblo, and Sioux population databases were established for the loci HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80. With the exception of HLA-DQA1, the loci appear to be almost as informative in the Native American population samples as for Caucasians, for identity testing purposes. HLA DQA1 is not as informative as the other loci, due to the high frequencies of the '3' and '4' alleles in these Native American groups. Except for GYPA in Navajos, the distribution of the genotype frequencies for the various loci meet Hardy Weinberg expectations. The deviation at the GYPA locus bad no affect on generating statistical estimates. Also, there is little evidence for departures from expectations of independence of alleles across loci. The data demonstrate that estimates of multiple locus profile frequencies can be obtained from the Native American databases for identity testing purposes using the product rule under the assumption of independence. In addition, the Navajo, Pueblo, and Sioux databases were more similar to each other than to U.S. Caucasians and African Americans.
AB - Navajo, Pueblo, and Sioux population databases were established for the loci HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80. With the exception of HLA-DQA1, the loci appear to be almost as informative in the Native American population samples as for Caucasians, for identity testing purposes. HLA DQA1 is not as informative as the other loci, due to the high frequencies of the '3' and '4' alleles in these Native American groups. Except for GYPA in Navajos, the distribution of the genotype frequencies for the various loci meet Hardy Weinberg expectations. The deviation at the GYPA locus bad no affect on generating statistical estimates. Also, there is little evidence for departures from expectations of independence of alleles across loci. The data demonstrate that estimates of multiple locus profile frequencies can be obtained from the Native American databases for identity testing purposes using the product rule under the assumption of independence. In addition, the Navajo, Pueblo, and Sioux databases were more similar to each other than to U.S. Caucasians and African Americans.
KW - Hardy- Weinberg expectations
KW - Navajo
KW - PCR
KW - Pueblo
KW - Sioux
KW - forensic science
KW - linkage equilibrium
KW - population databases
UR - http://www.scopus.com/inward/record.url?scp=0030071280&partnerID=8YFLogxK
U2 - 10.1520/jfs13895j
DO - 10.1520/jfs13895j
M3 - Article
C2 - 8934698
AN - SCOPUS:0030071280
SN - 0022-1198
VL - 41
SP - 47
EP - 51
JO - Journal of forensic sciences
JF - Journal of forensic sciences
IS - 1
ER -