Navajo, Pueblo, and Sioux population data on the loci HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80

Susan Scholl, Bruce Budowle, Kristin Radecki, Mark Salvo

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Navajo, Pueblo, and Sioux population databases were established for the loci HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80. With the exception of HLA-DQA1, the loci appear to be almost as informative in the Native American population samples as for Caucasians, for identity testing purposes. HLA DQA1 is not as informative as the other loci, due to the high frequencies of the '3' and '4' alleles in these Native American groups. Except for GYPA in Navajos, the distribution of the genotype frequencies for the various loci meet Hardy Weinberg expectations. The deviation at the GYPA locus bad no affect on generating statistical estimates. Also, there is little evidence for departures from expectations of independence of alleles across loci. The data demonstrate that estimates of multiple locus profile frequencies can be obtained from the Native American databases for identity testing purposes using the product rule under the assumption of independence. In addition, the Navajo, Pueblo, and Sioux databases were more similar to each other than to U.S. Caucasians and African Americans.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalJournal of Forensic Sciences
Volume41
Issue number1
Publication statusPublished - 23 Jan 1996

    Fingerprint

Keywords

  • Hardy- Weinberg expectations
  • Navajo
  • PCR
  • Pueblo
  • Sioux
  • forensic science
  • linkage equilibrium
  • population databases

Cite this