Nanoplasmonic platforms for bioassays

Zygmunt Gryczynski, Evgenia Matveeva, Tanya Shtoyko, Ewa Goldys, John Schetz, Julian Borejdo, Nils Calander, Ignacy Gryczynski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Surface-assembled thin molecular layers and nanostructures offer unique opportunities to study processes and mechanisms of macromolecular (protein-protein or/and protein-ligand) interactions. Possibility to capture the conformational information buried in quantum-level interactions offers unique opportunities for the dynamic monitoring of biophysical and biochemical processes at the molecular level. In this report we are presenting novel developments for bioassays with enhanced sensitivity and capabilities due to quantum-photonic interactions of a fluorescent reporter with metallic nanostructures. We discus three cases of plasmons: (1) in nanometer size particles (localized plasmons and metal enhanced fluorescence); (2) in thin metallic film (surface plasmons and directional surface plasmon coupled emeission SPCE); and (3) combination of nanoparticles with continous nanosurfaces (enhanced and directional emission). We will present examples of enhanced immunoassays, background suppression, and applications of this novel technology to the simultaneous measurement of changes in conformation, orientation and mass that occur when biomolecular complexes form.

Original languageEnglish
Title of host publicationProceedings of International Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006
Number of pages1
DOIs
StatePublished - 1 Dec 2006
EventInternational Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006 - Hangzhou, China
Duration: 16 Oct 200618 Oct 2006

Publication series

NameProceedings of International Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006

Other

OtherInternational Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006
CountryChina
CityHangzhou
Period16/10/0618/10/06

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  • Cite this

    Gryczynski, Z., Matveeva, E., Shtoyko, T., Goldys, E., Schetz, J., Borejdo, J., Calander, N., & Gryczynski, I. (2006). Nanoplasmonic platforms for bioassays. In Proceedings of International Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006 [4134787] (Proceedings of International Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006). https://doi.org/10.1109/METAMAT.2006.335048