Nanoparticle effects on human platelets in vitro: A comparison between PAMAM and triazine dendrimers

Alan E. Enciso, Barry Neun, Jamie Rodriguez, Amalendu Prakash Ranjan, Marina A. Dobrovolskaia, Eric E. Simanek

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Triazine and PAMAM dendrimers of similar size and number of cationic surface groups were compared for their ability to promote platelet aggregation. Triazine dendrimers (G3, G5 and G7) varied in molecular weight from 8 kDa-130 kDa and in surface groups 16-256. PAMAM dendrimers selected for comparison included G3 (7 kDa, 32 surface groups) and G6 (58 kDa, 256 surface groups). The treatment of human platelet-rich plasma (PRP) with low generation triazine dendrimers (0.01-1 μM) did not show any significant effect in human platelet aggregation in vitro; however, the treatment of PRP with larger generations promotes an effective aggregation. These results are in agreement with studies performed with PAMAM dendrimers, where large generations promote aggregation. Triazine dendrimers promote aggregation less aggressively than PAMAM dendrimers, a factor attributed to differences in cationic charge or the formation of supramolecular assemblies of dendrimers.

Original languageEnglish
Article number428
JournalMolecules
Volume21
Issue number4
DOIs
StatePublished - 1 Apr 2016

Fingerprint

Dendrimers
Triazines
dendrimers
Platelets
platelets
Nanoparticles
Blood Platelets
Agglomeration
nanoparticles
Platelet-Rich Plasma
Platelet Aggregation
Plasmas
Molecular Weight
Molecular weight
PAMAM Starburst
In Vitro Techniques
Therapeutics
assemblies
molecular weight

Keywords

  • Biocompatibility
  • Dendrimer
  • PAMAM
  • Platelet
  • Triazine

Cite this

Enciso, Alan E. ; Neun, Barry ; Rodriguez, Jamie ; Ranjan, Amalendu Prakash ; Dobrovolskaia, Marina A. ; Simanek, Eric E. / Nanoparticle effects on human platelets in vitro : A comparison between PAMAM and triazine dendrimers. In: Molecules. 2016 ; Vol. 21, No. 4.
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Nanoparticle effects on human platelets in vitro : A comparison between PAMAM and triazine dendrimers. / Enciso, Alan E.; Neun, Barry; Rodriguez, Jamie; Ranjan, Amalendu Prakash; Dobrovolskaia, Marina A.; Simanek, Eric E.

In: Molecules, Vol. 21, No. 4, 428, 01.04.2016.

Research output: Contribution to journalArticle

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