TY - JOUR
T1 - N-terminal truncations in sex steroid receptors and rapid steroid actions
AU - Schreihofer, Derek A.
AU - Duong, Phong
AU - Cunningham, Rebecca L.
N1 - Funding Information:
This study was funded by NIH National Institute of Neurological Disorders and Stroke ( R01 NS088514 ) to RLC and NIH National Institute of Aging ( R03 AG049255 ) to DAS and RLC.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/5
Y1 - 2018/5
N2 - Sex steroid receptors act as ligand activated nuclear transcription factors throughout the body, including the brain. However, post-translational modification of these receptors can direct them to extranuclear sites, including the plasma membrane, where they are able to initiate rapid signaling. Because of the conserved domain structure of these receptors, alternative exon splicing can result in proteins with altered nuclear and extranuclear actions. Although much attention has focused on internal and C-terminal splice variants, both estrogen and androgen receptors undergo N-terminal truncations, as well. These truncated proteins not only influence the transcriptional activity of the full-length receptors, but also associate with caveolin and initiate signaling at the plasma membrane. Such actions may have important physiological consequences in neuronal, endothelial, and cancer signaling and cell survival.
AB - Sex steroid receptors act as ligand activated nuclear transcription factors throughout the body, including the brain. However, post-translational modification of these receptors can direct them to extranuclear sites, including the plasma membrane, where they are able to initiate rapid signaling. Because of the conserved domain structure of these receptors, alternative exon splicing can result in proteins with altered nuclear and extranuclear actions. Although much attention has focused on internal and C-terminal splice variants, both estrogen and androgen receptors undergo N-terminal truncations, as well. These truncated proteins not only influence the transcriptional activity of the full-length receptors, but also associate with caveolin and initiate signaling at the plasma membrane. Such actions may have important physiological consequences in neuronal, endothelial, and cancer signaling and cell survival.
KW - Androgen receptor
KW - Estrogen receptor
KW - Membrane steroid receptor
KW - Splice variant
UR - http://www.scopus.com/inward/record.url?scp=85033598082&partnerID=8YFLogxK
U2 - 10.1016/j.steroids.2017.10.018
DO - 10.1016/j.steroids.2017.10.018
M3 - Article
C2 - 29104096
AN - SCOPUS:85033598082
SN - 0039-128X
VL - 133
SP - 15
EP - 20
JO - Steroids
JF - Steroids
ER -