Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

A. C. Novaes; P. Schaiquevich; G. Nasswetter; J. Marqués; M. Uchoa; L. Villanueva; S. Aguilera; J. Herrera Méndez; G. Hernández; G. Cotasio; R. Mantilla Hernández; R. Straka; L. Rojas; L. Zurita; M. Alanis; M. Gutiérrez; J. Ayala; T. Morales; C. Taylor; R. Garza; S. De La Garza Castro; N. M. Rodríguez; O. Lemus; J. Almada; I. Muñoz; H. Ramírez; G. Colado; S. Ureña; L. Bobadilla; A. Aldana; V. Larias; O. Ordóñez; R. Leonori; R. Jiménez; J. Romero; R. Acevedo; H. López; R. Galván; G. Venzes; J. Medélez; E. Barrera; J. Zepeda; L. Díaz; J. Aguilera; A. Borga Pérez; E. Lecona; R. Ble Campos; D. Herrera; J. Rivera; E. El Kouri; F. Vilchez; F. Peña; V. Crespo; A. Crespo; G. Chacón; V. Liendo; J. Iciarte; F. Mańriquez; Z. Jelenkovich; E. Marín; C. Rondón

Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

A. C. Novaes, P. Schaiquevich, G. Nasswetter, J. Marqués, M. Uchoa, L. Villanueva, S. Aguilera, J. Herrera Méndez, G. Hernández, G. Cotasio, R. Mantilla Hernández, R. Straka, L. Rojas, L. Zurita, M. Alanis, M. Gutiérrez, J. Ayala, T. Morales, C. Taylor, R. GarzaS. De La Garza Castro, N. M. Rodríguez, O. Lemus, J. Almada, I. Muñoz, H. Ramírez, G. Colado, S. Ureña, L. Bobadilla, A. Aldana, V. Larias, O. Ordóñez, R. Leonori, R. Jiménez, J. Romero, R. Acevedo, H. López, R. Galván, G. Venzes, J. Medélez, E. Barrera, J. Zepeda, L. Díaz, J. Aguilera, A. Borga Pérez, E. Lecona, R. Ble Campos, D. Herrera, J. Rivera, E. El Kouri, F. Vilchez, F. Peña, V. Crespo, A. Crespo, G. Chacón, V. Liendo, J. Iciarte, F. Mańriquez, Z. Jelenkovich, E. Marín, C. Rondón

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	International Journal of Clinical Pharmacology Research
Volume	25
Issue number	1
State	Published - 2005

Cite this

Novaes, A. C., Schaiquevich, P., Nasswetter, G., Marqués, J., Uchoa, M., Villanueva, L., Aguilera, S., Herrera Méndez, J., Hernández, G., Cotasio, G., Mantilla Hernández, R., Straka, R., Rojas, L., Zurita, L., Alanis, M., Gutiérrez, M., Ayala, J., Morales, T., Taylor, C., ... Rondón, C. (2005). Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis. International Journal of Clinical Pharmacology Research, 25(1), 1-7.

@article{dcc61bad3e0847e9bc8bf6782bbcf964,

title = "Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis",

abstract = "Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.",

author = "Novaes, {A. C.} and P. Schaiquevich and G. Nasswetter and J. Marqu{\'e}s and M. Uchoa and L. Villanueva and S. Aguilera and {Herrera M{\'e}ndez}, J. and G. Hern{\'a}ndez and G. Cotasio and {Mantilla Hern{\'a}ndez}, R. and R. Straka and L. Rojas and L. Zurita and M. Alanis and M. Guti{\'e}rrez and J. Ayala and T. Morales and C. Taylor and R. Garza and {De La Garza Castro}, S. and Rodr{\'i}guez, {N. M.} and O. Lemus and J. Almada and I. Mu{\~n}oz and H. Ram{\'i}rez and G. Colado and S. Ure{\~n}a and L. Bobadilla and A. Aldana and V. Larias and O. Ord{\'o}{\~n}ez and R. Leonori and R. Jim{\'e}nez and J. Romero and R. Acevedo and H. L{\'o}pez and R. Galv{\'a}n and G. Venzes and J. Med{\'e}lez and E. Barrera and J. Zepeda and L. D{\'i}az and J. Aguilera and {Borga P{\'e}rez}, A. and E. Lecona and {Ble Campos}, R. and D. Herrera and J. Rivera and {El Kouri}, E. and F. Vilchez and F. Pe{\~n}a and V. Crespo and A. Crespo and G. Chac{\'o}n and V. Liendo and J. Iciarte and F. Ma{\'n}riquez and Z. Jelenkovich and E. Mar{\'i}n and C. Rond{\'o}n",

year = "2005",

language = "English",

volume = "25",

pages = "1--7",

journal = "International Journal of Clinical Pharmacology Research",

issn = "0251-1649",

publisher = "Bioscience Ediprint Inc.",

number = "1",

}

Novaes, AC, Schaiquevich, P, Nasswetter, G, Marqués, J, Uchoa, M, Villanueva, L, Aguilera, S, Herrera Méndez, J, Hernández, G, Cotasio, G, Mantilla Hernández, R, Straka, R, Rojas, L, Zurita, L, Alanis, M, Gutiérrez, M, Ayala, J, Morales, T, Taylor, C, Garza, R, De La Garza Castro, S, Rodríguez, NM, Lemus, O, Almada, J, Muñoz, I, Ramírez, H, Colado, G, Ureña, S, Bobadilla, L, Aldana, A, Larias, V, Ordóñez, O, Leonori, R, Jiménez, R, Romero, J, Acevedo, R, López, H, Galván, R, Venzes, G, Medélez, J, Barrera, E, Zepeda, J, Díaz, L, Aguilera, J, Borga Pérez, A, Lecona, E, Ble Campos, R, Herrera, D, Rivera, J, El Kouri, E, Vilchez, F, Peña, F, Crespo, V, Crespo, A, Chacón, G, Liendo, V, Iciarte, J, Mańriquez, F, Jelenkovich, Z, Marín, E & Rondón, C 2005, 'Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis', International Journal of Clinical Pharmacology Research, vol. 25, no. 1, pp. 1-7.

TY - JOUR

T1 - Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

AU - Novaes, A. C.

AU - Schaiquevich, P.

AU - Nasswetter, G.

AU - Marqués, J.

AU - Uchoa, M.

AU - Villanueva, L.

AU - Aguilera, S.

AU - Herrera Méndez, J.

AU - Hernández, G.

AU - Cotasio, G.

AU - Mantilla Hernández, R.

AU - Straka, R.

AU - Rojas, L.

AU - Zurita, L.

AU - Alanis, M.

AU - Gutiérrez, M.

AU - Ayala, J.

AU - Morales, T.

AU - Taylor, C.

AU - Garza, R.

AU - De La Garza Castro, S.

AU - Rodríguez, N. M.

AU - Lemus, O.

AU - Almada, J.

AU - Muñoz, I.

AU - Ramírez, H.

AU - Colado, G.

AU - Ureña, S.

AU - Bobadilla, L.

AU - Aldana, A.

AU - Larias, V.

AU - Ordóñez, O.

AU - Leonori, R.

AU - Jiménez, R.

AU - Romero, J.

AU - Acevedo, R.

AU - López, H.

AU - Galván, R.

AU - Venzes, G.

AU - Medélez, J.

AU - Barrera, E.

AU - Zepeda, J.

AU - Díaz, L.

AU - Aguilera, J.

AU - Borga Pérez, A.

AU - Lecona, E.

AU - Ble Campos, R.

AU - Herrera, D.

AU - Rivera, J.

AU - El Kouri, E.

AU - Vilchez, F.

AU - Peña, F.

AU - Crespo, V.

AU - Crespo, A.

AU - Chacón, G.

AU - Liendo, V.

AU - Iciarte, J.

AU - Mańriquez, F.

AU - Jelenkovich, Z.

AU - Marín, E.

AU - Rondón, C.

PY - 2005

Y1 - 2005

N2 - Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

AB - Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

UR - http://www.scopus.com/inward/record.url?scp=20244368236&partnerID=8YFLogxK

M3 - Article

C2 - 15864872

AN - SCOPUS:20244368236

SN - 0251-1649

VL - 25

SP - 1

EP - 7

JO - International Journal of Clinical Pharmacology Research

JF - International Journal of Clinical Pharmacology Research

IS - 1

ER -

Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

Abstract

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