Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

A. C. Novaes, P. Schaiquevich, G. Nasswetter, J. Marqués, M. Uchoa, L. Villanueva, S. Aguilera, J. Herrera Méndez, G. Hernández, G. Cotasio, R. Mantilla Hernández, R. Straka, L. Rojas, L. Zurita, M. Alanis, M. Gutiérrez, J. Ayala, T. Morales, Charles Thomas Taylor, R. Garza & 41 others S. De La Garza Castro, N. M. Rodríguez, O. Lemus, J. Almada, I. Muñoz, H. Ramírez, G. Colado, S. Ureña, L. Bobadilla, A. Aldana, V. Larias, O. Ordóñez, R. Leonori, R. Jiménez, J. Romero, R. Acevedo, H. López, R. Galván, G. Venzes, J. Medélez, E. Barrera, J. Zepeda, L. Díaz, J. Aguilera, A. Borga Pérez, E. Lecona, R. Ble Campos, D. Herrera, J. Rivera, E. El Kouri, F. Vilchez, F. Peña, V. Crespo, A. Crespo, G. Chacón, V. Liendo, J. Iciarte, F. Mańriquez, Z. Jelenkovich, E. Marín, C. Rondón

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Abstract

Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Clinical Pharmacology Research
Volume25
Issue number1
StatePublished - 6 May 2005

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Knee Osteoarthritis
Hyaluronic Acid
Biotechnology
Multicenter Studies
Safety
Joints
Pain
Injections
Therapeutics

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Novaes, A. C., Schaiquevich, P., Nasswetter, G., Marqués, J., Uchoa, M., Villanueva, L., ... Rondón, C. (2005). Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis. International Journal of Clinical Pharmacology Research, 25(1), 1-7.
Novaes, A. C. ; Schaiquevich, P. ; Nasswetter, G. ; Marqués, J. ; Uchoa, M. ; Villanueva, L. ; Aguilera, S. ; Herrera Méndez, J. ; Hernández, G. ; Cotasio, G. ; Mantilla Hernández, R. ; Straka, R. ; Rojas, L. ; Zurita, L. ; Alanis, M. ; Gutiérrez, M. ; Ayala, J. ; Morales, T. ; Taylor, Charles Thomas ; Garza, R. ; De La Garza Castro, S. ; Rodríguez, N. M. ; Lemus, O. ; Almada, J. ; Muñoz, I. ; Ramírez, H. ; Colado, G. ; Ureña, S. ; Bobadilla, L. ; Aldana, A. ; Larias, V. ; Ordóñez, O. ; Leonori, R. ; Jiménez, R. ; Romero, J. ; Acevedo, R. ; López, H. ; Galván, R. ; Venzes, G. ; Medélez, J. ; Barrera, E. ; Zepeda, J. ; Díaz, L. ; Aguilera, J. ; Borga Pérez, A. ; Lecona, E. ; Ble Campos, R. ; Herrera, D. ; Rivera, J. ; El Kouri, E. ; Vilchez, F. ; Peña, F. ; Crespo, V. ; Crespo, A. ; Chacón, G. ; Liendo, V. ; Iciarte, J. ; Mańriquez, F. ; Jelenkovich, Z. ; Marín, E. ; Rondón, C. / Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis. In: International Journal of Clinical Pharmacology Research. 2005 ; Vol. 25, No. 1. pp. 1-7.
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abstract = "Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5{\%} of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.",
author = "Novaes, {A. C.} and P. Schaiquevich and G. Nasswetter and J. Marqu{\'e}s and M. Uchoa and L. Villanueva and S. Aguilera and {Herrera M{\'e}ndez}, J. and G. Hern{\'a}ndez and G. Cotasio and {Mantilla Hern{\'a}ndez}, R. and R. Straka and L. Rojas and L. Zurita and M. Alanis and M. Guti{\'e}rrez and J. Ayala and T. Morales and Taylor, {Charles Thomas} and R. Garza and {De La Garza Castro}, S. and Rodr{\'i}guez, {N. M.} and O. Lemus and J. Almada and I. Mu{\~n}oz and H. Ram{\'i}rez and G. Colado and S. Ure{\~n}a and L. Bobadilla and A. Aldana and V. Larias and O. Ord{\'o}{\~n}ez and R. Leonori and R. Jim{\'e}nez and J. Romero and R. Acevedo and H. L{\'o}pez and R. Galv{\'a}n and G. Venzes and J. Med{\'e}lez and E. Barrera and J. Zepeda and L. D{\'i}az and J. Aguilera and {Borga P{\'e}rez}, A. and E. Lecona and {Ble Campos}, R. and D. Herrera and J. Rivera and {El Kouri}, E. and F. Vilchez and F. Pe{\~n}a and V. Crespo and A. Crespo and G. Chac{\'o}n and V. Liendo and J. Iciarte and F. Mańriquez and Z. Jelenkovich and E. Mar{\'i}n and C. Rond{\'o}n",
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Novaes, AC, Schaiquevich, P, Nasswetter, G, Marqués, J, Uchoa, M, Villanueva, L, Aguilera, S, Herrera Méndez, J, Hernández, G, Cotasio, G, Mantilla Hernández, R, Straka, R, Rojas, L, Zurita, L, Alanis, M, Gutiérrez, M, Ayala, J, Morales, T, Taylor, CT, Garza, R, De La Garza Castro, S, Rodríguez, NM, Lemus, O, Almada, J, Muñoz, I, Ramírez, H, Colado, G, Ureña, S, Bobadilla, L, Aldana, A, Larias, V, Ordóñez, O, Leonori, R, Jiménez, R, Romero, J, Acevedo, R, López, H, Galván, R, Venzes, G, Medélez, J, Barrera, E, Zepeda, J, Díaz, L, Aguilera, J, Borga Pérez, A, Lecona, E, Ble Campos, R, Herrera, D, Rivera, J, El Kouri, E, Vilchez, F, Peña, F, Crespo, V, Crespo, A, Chacón, G, Liendo, V, Iciarte, J, Mańriquez, F, Jelenkovich, Z, Marín, E & Rondón, C 2005, 'Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis', International Journal of Clinical Pharmacology Research, vol. 25, no. 1, pp. 1-7.

Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis. / Novaes, A. C.; Schaiquevich, P.; Nasswetter, G.; Marqués, J.; Uchoa, M.; Villanueva, L.; Aguilera, S.; Herrera Méndez, J.; Hernández, G.; Cotasio, G.; Mantilla Hernández, R.; Straka, R.; Rojas, L.; Zurita, L.; Alanis, M.; Gutiérrez, M.; Ayala, J.; Morales, T.; Taylor, Charles Thomas; Garza, R.; De La Garza Castro, S.; Rodríguez, N. M.; Lemus, O.; Almada, J.; Muñoz, I.; Ramírez, H.; Colado, G.; Ureña, S.; Bobadilla, L.; Aldana, A.; Larias, V.; Ordóñez, O.; Leonori, R.; Jiménez, R.; Romero, J.; Acevedo, R.; López, H.; Galván, R.; Venzes, G.; Medélez, J.; Barrera, E.; Zepeda, J.; Díaz, L.; Aguilera, J.; Borga Pérez, A.; Lecona, E.; Ble Campos, R.; Herrera, D.; Rivera, J.; El Kouri, E.; Vilchez, F.; Peña, F.; Crespo, V.; Crespo, A.; Chacón, G.; Liendo, V.; Iciarte, J.; Mańriquez, F.; Jelenkovich, Z.; Marín, E.; Rondón, C.

In: International Journal of Clinical Pharmacology Research, Vol. 25, No. 1, 06.05.2005, p. 1-7.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

AU - Novaes, A. C.

AU - Schaiquevich, P.

AU - Nasswetter, G.

AU - Marqués, J.

AU - Uchoa, M.

AU - Villanueva, L.

AU - Aguilera, S.

AU - Herrera Méndez, J.

AU - Hernández, G.

AU - Cotasio, G.

AU - Mantilla Hernández, R.

AU - Straka, R.

AU - Rojas, L.

AU - Zurita, L.

AU - Alanis, M.

AU - Gutiérrez, M.

AU - Ayala, J.

AU - Morales, T.

AU - Taylor, Charles Thomas

AU - Garza, R.

AU - De La Garza Castro, S.

AU - Rodríguez, N. M.

AU - Lemus, O.

AU - Almada, J.

AU - Muñoz, I.

AU - Ramírez, H.

AU - Colado, G.

AU - Ureña, S.

AU - Bobadilla, L.

AU - Aldana, A.

AU - Larias, V.

AU - Ordóñez, O.

AU - Leonori, R.

AU - Jiménez, R.

AU - Romero, J.

AU - Acevedo, R.

AU - López, H.

AU - Galván, R.

AU - Venzes, G.

AU - Medélez, J.

AU - Barrera, E.

AU - Zepeda, J.

AU - Díaz, L.

AU - Aguilera, J.

AU - Borga Pérez, A.

AU - Lecona, E.

AU - Ble Campos, R.

AU - Herrera, D.

AU - Rivera, J.

AU - El Kouri, E.

AU - Vilchez, F.

AU - Peña, F.

AU - Crespo, V.

AU - Crespo, A.

AU - Chacón, G.

AU - Liendo, V.

AU - Iciarte, J.

AU - Mańriquez, F.

AU - Jelenkovich, Z.

AU - Marín, E.

AU - Rondón, C.

PY - 2005/5/6

Y1 - 2005/5/6

N2 - Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

AB - Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

UR - http://www.scopus.com/inward/record.url?scp=20244368236&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 1

EP - 7

JO - International Journal of Clinical Pharmacology Research

JF - International Journal of Clinical Pharmacology Research

SN - 0251-1649

IS - 1

ER -