Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis

A. C. Novaes, P. Schaiquevich, G. Nasswetter, J. Marqués, M. Uchoa, L. Villanueva, S. Aguilera, J. Herrera Méndez, G. Hernández, G. Cotasio, R. Mantilla Hernández, R. Straka, L. Rojas, L. Zurita, M. Alanis, M. Gutiérrez, J. Ayala, T. Morales, C. Taylor, R. GarzaS. De La Garza Castro, N. M. Rodríguez, O. Lemus, J. Almada, I. Muñoz, H. Ramírez, G. Colado, S. Ureña, L. Bobadilla, A. Aldana, V. Larias, O. Ordóñez, R. Leonori, R. Jiménez, J. Romero, R. Acevedo, H. López, R. Galván, G. Venzes, J. Medélez, E. Barrera, J. Zepeda, L. Díaz, J. Aguilera, A. Borga Pérez, E. Lecona, R. Ble Campos, D. Herrera, J. Rivera, E. El Kouri, F. Vilchez, F. Peña, V. Crespo, A. Crespo, G. Chacón, V. Liendo, J. Iciarte, F. Mańriquez, Z. Jelenkovich, E. Marín, C. Rondón

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Abstract

Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multicenter study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. The parameters studied were pain (six items), stiffness (two items) and functional capacity (17 items). The parameters were evaluated 1 week after the corresponding injection. Statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration (p < 0.05). Intra-articular HA administration was well tolerated. Treatment-related nonserious adverse events were registered in 2.5% of administrations. Based on the results obtained, HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Clinical Pharmacology Research
Volume25
Issue number1
Publication statusPublished - 6 May 2005

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Novaes, A. C., Schaiquevich, P., Nasswetter, G., Marqués, J., Uchoa, M., Villanueva, L., ... Rondón, C. (2005). Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis. International Journal of Clinical Pharmacology Research, 25(1), 1-7.