MTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo

Chunguang Yang, Jianhua Peng, Wen Jing Jiang, Yue Zhang, Xiaoyun Chen, Xianmin Wu, Yi Zhu, Huxiang Zhang, Jianfu Chen, Jixian Wang, William C.S. Cho, Kunlin Jin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The mammalian target of rapamycin (mTOR) signaling is a key pathway in the progression of different cancers and in the homeostasis of stem cells. Here, we investigated the link between mTOR signaling and cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC). We found that human primary NPC expressed embryonic stem cell (ESC) markers: CD133, SOX2 and OCT4 as well as pmTOR and pS6. Primary ESC-positive NPC cells could form secondary NPC in BALB/c nude mice. Rapamycin, an mTOR inhibitor, significantly suppressed ESC-positive NPC cell growth in vitro and tumor formation in vivo. Our findings suggest that mTOR signaling is activated in CSC-like cells and plays an important role in NPC growth.

Original languageEnglish
Pages (from-to)186-194
Number of pages9
JournalCancer Letters
Volume341
Issue number2
DOIs
StatePublished - 1 Dec 2013

Keywords

  • Cancer stem cells
  • MTOR signaling
  • Nasopharyngeal carcinoma
  • Rapamycin

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    Yang, C., Peng, J., Jiang, W. J., Zhang, Y., Chen, X., Wu, X., Zhu, Y., Zhang, H., Chen, J., Wang, J., Cho, W. C. S., & Jin, K. (2013). MTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo. Cancer Letters, 341(2), 186-194. https://doi.org/10.1016/j.canlet.2013.08.004