MSC studies in large-animal models

Bruce A. Bunnell, Christine Gagliardi, Maria Isabel Ribeiro Dias

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mesenchymal stromal cells found within bone marrow, fat, and other tissues are a population of cells with the potential to mediate therapeutic outcomes based on differentiation into multiple cell lineages or through paracrine-mediated mechanisms that influence angiogenesis, apoptosis, or immune response. Currently, mesenchymal stromal cells are being widely investigated for numerous tissue engineering and regenerative medicine applications. Appropriate animal models will be crucial to the development and evaluation of regenerative medicine-based treatments and eventual cures for debilitating diseases. Here, we summarize the ongoing research focused on studying the biological and therapeutic potential of mesenchymal stromal cells in large-animal models.

Original languageEnglish
Title of host publicationMesenchymal Stromal Cells
Subtitle of host publicationBiology and Clinical Applications
PublisherSpringer New York
Pages237-258
Number of pages22
ISBN (Electronic)9781461457114
ISBN (Print)9781461457107
DOIs
StatePublished - 1 Jan 2013

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    Bunnell, B. A., Gagliardi, C., & Dias, M. I. R. (2013). MSC studies in large-animal models. In Mesenchymal Stromal Cells: Biology and Clinical Applications (pp. 237-258). Springer New York. https://doi.org/10.1007/978-1-4614-5711-4_13