MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas

Pooyan Khalighinejad, Eul Hyun Suh, A. Dean Sherry

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The role of Zn2+ ions in proper storage of insulin in β-cell granules is well-established so when insulin is secreted from β-cells stimulated by an increase in plasma glucose, free Zn2+ ions are also released. This local increase in Zn2+ can be detected in the pancreas of rodents in real time by the use of a zinc-responsive MR contrast agent. This method offers the opportunity to monitor β-cell function longitudinally in live rodents. The methods used in our lab are fully described in this short report and some MR images of a rat pancreas showing clearly enhanced hot spots in the tail are presented.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages11
StatePublished - 2023

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


Dive into the research topics of 'MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas'. Together they form a unique fingerprint.

Cite this