TY - JOUR
T1 - MRI biomarkers of small vessel disease and cognition
T2 - A cross-sectional study of a cognitively normal Mexican American cohort
AU - The Health and Aging Brain Study (HABS-HD) Study Team
AU - Vintimilla, Raul
AU - Hall, James
AU - King, Kevin
AU - Braskie, Meredith N.
AU - Johnson, Leigh
AU - Yaffe, Kristine
AU - Toga, Arthur W.
AU - O'Bryant, Sid
N1 - Funding Information:
Sid O'Bryant has multiple patents in neurodegenerative diseases and is the founding scientist for Cx Precision Medicine, Inc. Sid O'Bryant has received grants from the Michael J Fox Foundation. Leigh Johnson owns an interest in Cx Precision Medicine, Inc. Meredith Braskie has received payments for teaching at the University of Southern California where she also receives a stipend for her role as Director of Education at the Stevens Neuroimaging and Informatics Institute. Kristine Yaffe has received grants from the NIH, Department of Defense, Alzheimer's Drug Discovery Foundation, and Doris Duke Foundation. Kristine Yaffe has participated on the Data Safety Monitoring Board or Advisory Board of NIA and Ely Lilly, she also has a role at Alector Inc. Kristine Yaffe has received support for attending AAIC, Beeson, and NIH conferences. Raul Vintimilla, James Hall, Kevin King, and Arthur W. Toga report no conflict of interest.
Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association
PY - 2021
Y1 - 2021
N2 - Background: The current project sought to evaluate the impact that white matter hyperintensities (WMH) have on executive function in cognitively normal Mexican Americans, an underserved population with onset and more rapid progression of dementia. Methods: Data from 515 participants (360 female) enrolled in the Health and Aging Brain Study: Health Disparities project were analyzed. Participants underwent clinical evaluation, cognitive testing, and a brain MRI. Linear regression was used to predict the effect of total WMH volume on cognitive test scores. Age, sex, and education were entered as covariates. Results: Regression analysis showed that WMH volume significantly predicted executive function. WMH also predicted global cognition and attention scores, although not significantly after adjusting for age. Conclusion: In this sample of cognitively normal Mexican Americans, we found that WMH volume was associated with lower scores in a measure of executive function, after accounting for age, sex, and education.
AB - Background: The current project sought to evaluate the impact that white matter hyperintensities (WMH) have on executive function in cognitively normal Mexican Americans, an underserved population with onset and more rapid progression of dementia. Methods: Data from 515 participants (360 female) enrolled in the Health and Aging Brain Study: Health Disparities project were analyzed. Participants underwent clinical evaluation, cognitive testing, and a brain MRI. Linear regression was used to predict the effect of total WMH volume on cognitive test scores. Age, sex, and education were entered as covariates. Results: Regression analysis showed that WMH volume significantly predicted executive function. WMH also predicted global cognition and attention scores, although not significantly after adjusting for age. Conclusion: In this sample of cognitively normal Mexican Americans, we found that WMH volume was associated with lower scores in a measure of executive function, after accounting for age, sex, and education.
KW - MRI
KW - Mexican American
KW - cardiovascular risk factors
KW - cerebral small vessel disease
KW - cognition
UR - http://www.scopus.com/inward/record.url?scp=85133978385&partnerID=8YFLogxK
U2 - 10.1002/dad2.12236
DO - 10.1002/dad2.12236
M3 - Article
AN - SCOPUS:85133978385
SN - 2352-8729
VL - 13
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12236
ER -