Motor responses of autoimmune NZB/B1NJ and C57BL/6Nnia mice to arecoline and nicotine

Konrad C. Retz, Clayton K. Trimmer, Michael J. Forster, Harbans Lal

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In 11-13 month C57BL/6Nnia mice, arecoline produced a dose-dependent decrease in motor activity at doses of 0.64-2.5 mg/kg, whereas at doses of 5.0-20.0 mg/kg arecoline produced a dose-dependent increase in motor activity. In marked contrast, age-matched NZB/B1NJ (New Zealand Black) mice failed to exhibit the first phase of the response, but showed a greater dose-dependent increase in motor activity following the doses of 10 and 20 mg/kg. Nicotine, 0.64-2.5 mg/kg, produced a dose-dependent decrease in motor activity in both strains. The effects of arecoline and nicotine were antagonized by scopolamine (2.5 mg/kg) and mecamylamine (1.0 mg/kg), respectively. These findings suggest that muscarinic neurotransmission may be altered in NZB/B1NJ mice, which produce brain-reactive autoantibodies, exhibit learning/memory dysfunctions, and also exhibit a loss of neurons staining positive for choline acetyltransferase.

Original languageEnglish
Pages (from-to)275-282
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume28
Issue number2
DOIs
StatePublished - Oct 1987

Keywords

  • Arecoline
  • Autoimmunity
  • C57BL/6Nnia mice
  • Mecamylamine
  • Motor activity
  • NZB/B1NJ mice
  • Nicotine
  • Scopolamine

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