Abstract
In 11-13 month C57BL/6Nnia mice, arecoline produced a dose-dependent decrease in motor activity at doses of 0.64-2.5 mg/kg, whereas at doses of 5.0-20.0 mg/kg arecoline produced a dose-dependent increase in motor activity. In marked contrast, age-matched NZB/B1NJ (New Zealand Black) mice failed to exhibit the first phase of the response, but showed a greater dose-dependent increase in motor activity following the doses of 10 and 20 mg/kg. Nicotine, 0.64-2.5 mg/kg, produced a dose-dependent decrease in motor activity in both strains. The effects of arecoline and nicotine were antagonized by scopolamine (2.5 mg/kg) and mecamylamine (1.0 mg/kg), respectively. These findings suggest that muscarinic neurotransmission may be altered in NZB/B1NJ mice, which produce brain-reactive autoantibodies, exhibit learning/memory dysfunctions, and also exhibit a loss of neurons staining positive for choline acetyltransferase.
Original language | English |
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Pages (from-to) | 275-282 |
Number of pages | 8 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Oct 1987 |
Keywords
- Arecoline
- Autoimmunity
- C57BL/6Nnia mice
- Mecamylamine
- Motor activity
- NZB/B1NJ mice
- Nicotine
- Scopolamine