Monosomy 7 and activating RAS mutations accompany malignant transformation in patients with congenital neutropenia

Medicine & Life Sciences

• Neutropenia, Severe Congenital, Autosomal Recessive 3 100%
• Monosomy Chromosome 7 98%
• Granulocyte Colony-Stimulating Factor 45%
• Myelodysplastic Syndromes 35%
• Mutation 35%
• Acute Myeloid Leukemia 30%
• Severe chronic Neutropenia 19%
• Bone Marrow 15%
• Myelopoiesis 15%
• Congenital, Hereditary, and Neonatal Diseases and Abnormalities 13%
• Myeloid Leukemia 12%
• Cytogenetics 10%
• Chromosome Aberrations 10%
• Infections 10%
• Therapeutic Uses 8%
• Intercellular Signaling Peptides and Proteins 8%
• Neutrophils 8%
• Quality of Life 6%
• Therapeutics 5%

Chemical Compounds

• Colony Stimulating Factor 94%
• Mutation 53%
• Cytogenetics 44%
• Chemical Transformation 39%
• Growth Factor 18%
• Disorder 13%