Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Yang I. Lin, Panayota Bitha, Zhong Li, Subas M. Sakya, Timothy W. Strohmeyer, Stanley A. Lang, Youjun Yang, Niraja Bhachech, William J. Weiss, Peter J. Petersen, Nilda V. Jacobus, Karen Bush, Raymond T. Testa

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Abstract

Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.

Original languageEnglish
Pages (from-to)1811-1816
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number14
DOIs
StatePublished - 22 Jul 1997

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    Lin, Y. I., Bitha, P., Li, Z., Sakya, S. M., Strohmeyer, T. W., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K., & Testa, R. T. (1997). Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems. Bioorganic and Medicinal Chemistry Letters, 7(14), 1811-1816. https://doi.org/10.1016/S0960-894X(97)00305-3