Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Yang I. Lin; Panayota Bitha; Zhong Li; Subas M. Sakya; Timothy W. Strohmeyer; Stanley A. Lang; Youjun Yang; Niraja Bhachech; William J. Weiss; Peter J. Petersen; Nilda V. Jacobus; Karen Bush; Raymond T. Testa

doi:10.1016/S0960-894X(97)00305-3

Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Yang I. Lin, Panayota Bitha, Zhong Li, Subas M. Sakya, Timothy W. Strohmeyer, Stanley A. Lang, Youjun Yang, Niraja Bhachech, William J. Weiss, Peter J. Petersen, Nilda V. Jacobus, Karen Bush, Raymond T. Testa

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Abstract

Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.

Original language	English
Pages (from-to)	1811-1816
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(97)00305-3
State	Published - 22 Jul 1997

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Lin, Y. I., Bitha, P., Li, Z., Sakya, S. M., Strohmeyer, T. W., Lang, S. A., Yang, Y., Bhachech, N., Weiss, W. J., Petersen, P. J., Jacobus, N. V., Bush, K., & Testa, R. T. (1997). Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems. Bioorganic and Medicinal Chemistry Letters, 7(14), 1811-1816. https://doi.org/10.1016/S0960-894X(97)00305-3

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title = "Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems",

abstract = "Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.",

author = "Lin, {Yang I.} and Panayota Bitha and Zhong Li and Sakya, {Subas M.} and Strohmeyer, {Timothy W.} and Lang, {Stanley A.} and Youjun Yang and Niraja Bhachech and Weiss, {William J.} and Petersen, {Peter J.} and Jacobus, {Nilda V.} and Karen Bush and Testa, {Raymond T.}",

year = "1997",

month = jul,

day = "22",

doi = "10.1016/S0960-894X(97)00305-3",

language = "English",

volume = "7",

pages = "1811--1816",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

AU - Lin, Yang I.

AU - Bitha, Panayota

AU - Li, Zhong

AU - Sakya, Subas M.

AU - Strohmeyer, Timothy W.

AU - Lang, Stanley A.

AU - Yang, Youjun

AU - Bhachech, Niraja

AU - Weiss, William J.

AU - Petersen, Peter J.

AU - Jacobus, Nilda V.

AU - Bush, Karen

AU - Testa, Raymond T.

PY - 1997/7/22

Y1 - 1997/7/22

N2 - Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.

AB - Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.

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U2 - 10.1016/S0960-894X(97)00305-3

DO - 10.1016/S0960-894X(97)00305-3

M3 - Article

AN - SCOPUS:0030816697

VL - 7

SP - 1811

EP - 1816

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 14

ER -

Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Abstract

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