Molecular mechanisms of maternal vascular dysfunction in preeclampsia

Styliani Goulopoulou, Sandra T. Davidge

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations


•Endothelium-derived factor production and signaling are altered in preeclampsia.•Placenta-derived factors induce systemic maternal vascular dysfunction. In preeclampsia, as a heterogeneous syndrome, multiple pathways have been proposed for both the causal as well as the perpetuating factors leading to maternal vascular dysfunction. Postulated mechanisms include imbalance in the bioavailability and activity of endothelium-derived contracting and relaxing factors and oxidative stress. Studies have shown that placenta-derived factors [antiangiogenic factors, microparticles (MPs), cell-free nucleic acids] are released into the maternal circulation and act on the vascular wall to modify the secretory capacity of endothelial cells and alter the responsiveness of vascular smooth muscle cells to constricting and relaxing stimuli. These molecules signal their deleterious effects on the maternal vascular wall via pathways that provide the molecular basis for novel and effective therapeutic interventions.

Original languageEnglish
Pages (from-to)88-97
Number of pages10
JournalTrends in Molecular Medicine
Issue number2
StatePublished - 1 Feb 2015


  • Endothelial function
  • Hypertension
  • Preeclampsia
  • Pregnancy


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