Molecular Markers of Amnestic Mild Cognitive Impairment among Mexican Americans

Melissa Edwards, James Hall, Benjamin Williams, Leigh A. Johnson, Sidney O'Bryant

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Background: Mexican Americans face a significant health disparity when it comes to Alzheimer's disease (AD) as they present with higher rates of the disease and develop AD at an earlier age compared to other ethnic groups. Recent work identified a proteomic profile of AD among this population; however, no work to date has sought to examine the biological profile of pre-AD among Mexican Americans. Objective: This study aims to identify an amnestic mild cognitive impairment (aMCI) proteomic profile among Mexican Americans. Methods: Data were analyzed from 284 Mexican American participants (aMCI, n = 73; normal controls, n = 211) from the Health & Aging Brain among Latino Elders study. Fasting serum samples were analyzed using a multi-plex biomarker assay platform. A biomarker profile was generated using random forest analyses. Results: Among aMCI cases, the biomarker profile was found to be largely inflammatory with the top three markers shown to include TNFβ, IL10, and TARC. The overall diagnostic accuracy of the biomarkers in detecting aMCI was 96% (sensitivity = 0.82; specificity = 0.97). Inclusion of clinical variables with the selected biomarkers did not impact the overall detection accuracy (area under the curve = 0.96) but led to a slight improvement in specificity (specificity = 0.99) and decrease in sensitivity (sensitivity = 0.74). Conclusion: The biomarker profile of aMCI was shown to be different from our previously generated AD profile among Mexican Americans, which was largely metabolic in nature. The findings implicate a possible interplay between inflammatory and metabolic processes and additional work is needed to further examine this.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalJournal of Alzheimer's Disease
Volume49
Issue number1
DOIs
StatePublished - 1 Jan 2015

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Biomarkers
Alzheimer Disease
Proteomics
Health
Hispanic Americans
Ethnic Groups
Interleukin-10
Area Under Curve
Cognitive Dysfunction
Fasting
Sensitivity and Specificity
Brain
Serum
Population

Keywords

  • Amnestic
  • Mexican American
  • biomarker
  • mild cognitive impairment

Cite this

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title = "Molecular Markers of Amnestic Mild Cognitive Impairment among Mexican Americans",
abstract = "Background: Mexican Americans face a significant health disparity when it comes to Alzheimer's disease (AD) as they present with higher rates of the disease and develop AD at an earlier age compared to other ethnic groups. Recent work identified a proteomic profile of AD among this population; however, no work to date has sought to examine the biological profile of pre-AD among Mexican Americans. Objective: This study aims to identify an amnestic mild cognitive impairment (aMCI) proteomic profile among Mexican Americans. Methods: Data were analyzed from 284 Mexican American participants (aMCI, n = 73; normal controls, n = 211) from the Health & Aging Brain among Latino Elders study. Fasting serum samples were analyzed using a multi-plex biomarker assay platform. A biomarker profile was generated using random forest analyses. Results: Among aMCI cases, the biomarker profile was found to be largely inflammatory with the top three markers shown to include TNFβ, IL10, and TARC. The overall diagnostic accuracy of the biomarkers in detecting aMCI was 96{\%} (sensitivity = 0.82; specificity = 0.97). Inclusion of clinical variables with the selected biomarkers did not impact the overall detection accuracy (area under the curve = 0.96) but led to a slight improvement in specificity (specificity = 0.99) and decrease in sensitivity (sensitivity = 0.74). Conclusion: The biomarker profile of aMCI was shown to be different from our previously generated AD profile among Mexican Americans, which was largely metabolic in nature. The findings implicate a possible interplay between inflammatory and metabolic processes and additional work is needed to further examine this.",
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Molecular Markers of Amnestic Mild Cognitive Impairment among Mexican Americans. / Edwards, Melissa; Hall, James; Williams, Benjamin; Johnson, Leigh A.; O'Bryant, Sidney.

In: Journal of Alzheimer's Disease, Vol. 49, No. 1, 01.01.2015, p. 221-228.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Edwards, Melissa

AU - Hall, James

AU - Williams, Benjamin

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N2 - Background: Mexican Americans face a significant health disparity when it comes to Alzheimer's disease (AD) as they present with higher rates of the disease and develop AD at an earlier age compared to other ethnic groups. Recent work identified a proteomic profile of AD among this population; however, no work to date has sought to examine the biological profile of pre-AD among Mexican Americans. Objective: This study aims to identify an amnestic mild cognitive impairment (aMCI) proteomic profile among Mexican Americans. Methods: Data were analyzed from 284 Mexican American participants (aMCI, n = 73; normal controls, n = 211) from the Health & Aging Brain among Latino Elders study. Fasting serum samples were analyzed using a multi-plex biomarker assay platform. A biomarker profile was generated using random forest analyses. Results: Among aMCI cases, the biomarker profile was found to be largely inflammatory with the top three markers shown to include TNFβ, IL10, and TARC. The overall diagnostic accuracy of the biomarkers in detecting aMCI was 96% (sensitivity = 0.82; specificity = 0.97). Inclusion of clinical variables with the selected biomarkers did not impact the overall detection accuracy (area under the curve = 0.96) but led to a slight improvement in specificity (specificity = 0.99) and decrease in sensitivity (sensitivity = 0.74). Conclusion: The biomarker profile of aMCI was shown to be different from our previously generated AD profile among Mexican Americans, which was largely metabolic in nature. The findings implicate a possible interplay between inflammatory and metabolic processes and additional work is needed to further examine this.

AB - Background: Mexican Americans face a significant health disparity when it comes to Alzheimer's disease (AD) as they present with higher rates of the disease and develop AD at an earlier age compared to other ethnic groups. Recent work identified a proteomic profile of AD among this population; however, no work to date has sought to examine the biological profile of pre-AD among Mexican Americans. Objective: This study aims to identify an amnestic mild cognitive impairment (aMCI) proteomic profile among Mexican Americans. Methods: Data were analyzed from 284 Mexican American participants (aMCI, n = 73; normal controls, n = 211) from the Health & Aging Brain among Latino Elders study. Fasting serum samples were analyzed using a multi-plex biomarker assay platform. A biomarker profile was generated using random forest analyses. Results: Among aMCI cases, the biomarker profile was found to be largely inflammatory with the top three markers shown to include TNFβ, IL10, and TARC. The overall diagnostic accuracy of the biomarkers in detecting aMCI was 96% (sensitivity = 0.82; specificity = 0.97). Inclusion of clinical variables with the selected biomarkers did not impact the overall detection accuracy (area under the curve = 0.96) but led to a slight improvement in specificity (specificity = 0.99) and decrease in sensitivity (sensitivity = 0.74). Conclusion: The biomarker profile of aMCI was shown to be different from our previously generated AD profile among Mexican Americans, which was largely metabolic in nature. The findings implicate a possible interplay between inflammatory and metabolic processes and additional work is needed to further examine this.

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