Molecular insights on the possible role of annexin A2 in COVID-19 pathogenesis and post-infection complications

Prakash Patil, Praveenkumar Shetty, K. K. Nithin, Pavan Gollapalli, Sukanya Shetty, Roopa Bhandary, Jamboor K. Vishwanatha, Sudeep D. Ghate

Research output: Contribution to journalReview articlepeer-review

Abstract

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has infected >235 million people and killed over 4.8 million individuals worldwide. Although vaccines have been developed for prophylactic management, there are no clinically proven antivirals to treat the viral infection. Continuous efforts are being made all over the world to develop effective drugs but these are being delayed by periodic outbreak of mutated SARS-CoV-2 and a lack of knowledge of molecular mechanisms underlying viral pathogenesis and post-infection complications. In this regard, the involvement of Annexin A2 (AnxA2), a lipid-raft related phospholipid-binding protein, in SARS-CoV-2 attachment, internalization, and replication has been discussed. In addition to the evidence from published literature, we have performed in silico docking of viral spike glycoprotein and RNA-dependent RNA polymerase with human AnxA2 to find the molecular interactions. Overall, this review provides the molecular insights into a potential role of AnxA2 in the SARS-CoV-2 pathogenesis and post-infection complications, especially thrombosis, cytokine storm, and insulin resistance.

Original languageEnglish
Article number11028
JournalInternational journal of molecular sciences
Volume22
Issue number20
DOIs
StatePublished - 1 Oct 2021

Keywords

  • Annexin A2
  • COVID-19
  • Cytokine storm
  • Infection
  • Insulin resistance
  • Pathogenesis
  • SARS-CoV-2
  • Thrombosis

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