Abstract
Background: STIM1 gates TRPC channels, but the interacting domains are unknown. Results: The TRPC N and C terminus coiled coil domains interact to restrict access of STIM1. Their dissociation by cell stimulation promotes STIM1 interaction. Conclusion: The STIM1 Orai1-activating region (SOAR) domain interacts with the TRPC C terminus CCD to open the channels. Significance: The findings reveal how STIM1 opens the TRPC channels to control receptor-stimulated Ca2+ influx.
Original language | English |
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Pages (from-to) | 6372-6382 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 10 |
DOIs | |
State | Published - 7 Mar 2014 |