Modulation of K_Ca channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model

Keyphrases

• BK Channel 100%
• Brain Tumor 100%
• Brain Drug Delivery 100%
• Anticancer Drug Delivery 100%
• Xenograft Model 100%
• Temozolomide 77%
• Herceptin 55%
• Tumor Barriers 44%
• Brain Tumor Patients 22%
• Her2neu 22%
• Antitumor Activity 22%
• Potassium Channel 22%
• Antitumor Effect 11%
• Overexpressing 11%
• Channel Activity 11%
• Clinical Outcomes 11%
• Antineoplastic Agents 11%
• Anticancer Drugs 11%
• Potassium 11%
• Calcium-dependent 11%
• Glioma 11%
• Glioma Tissue 11%
• Human Epidermal Growth Factor Receptor 2 (HER2) 11%
• Combination Treatment 11%
• Antibody Delivery 11%
• Nude Mice 11%
• Glioma Model 11%
• Trastuzumab 11%
• Agent Delivery 11%
• Carboplatin 11%
• Blood-brain Tumor Barrier 11%
• Co-infusion 11%
• Patient Survival 11%
• Therapeutic Levels 11%
• Channel Expression 11%
• Brain Cancer Cells 11%
• Novel Drug Delivery System 11%
• Advanced Drug Delivery 11%
• Glial Tumors 11%
• Human Glioma 11%
• Active Efflux System 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Anticarcinogen 100%
• Intracranial Tumor 100%
• Temozolomide 53%
• Trastuzumab 46%
• Carbon 14 15%
• Potassium Channel 15%
• Antitumor Activity 15%
• Effusion 7%
• Nude Mouse 7%
• Carboplatin 7%
• Drug Delivery System 7%
• Isotopes of Potassium 7%
• Glioma 7%
• Blood-Brain Barrier 7%

Neuroscience

• Anticarcinogen 100%
• Intracranial Tumor 100%
• Temozolomide 53%
• Trastuzumab 46%
• Agonist 38%
• Potassium Channel 15%
• Blood Brain Barrier 7%
• Carboplatin 7%