Modulation of astrocyte phenotype in response to T-cell interaction

Jessica Hersh, Jude Prah, Ali Winters, Ran Liu, Shao Hua Yang

Research output: Contribution to journalArticlepeer-review

Abstract

We determined that T-cell astrocyte interaction modulates interleukin-10 (IL-10) production from both cell types. The impact of IL-10 on astrocytes was compared to IL-10 generated from T-cell-astrocyte interactions in vitro. We demonstrated that T-cells directly interact with astrocytes to upregulate gene expression and secretion of IL-10, confirmed by elevated STAT3p/STAT3 expression in astrocytes. IL-10 increased astrocytes proliferation. In addition, IL-10 treatment and CD4+ co-culture shifts primary astrocytes toward a more energetic phenotype. These findings indicate that direct interaction of CD4+ T-cells with astrocytes, activated the IL-10 anti-inflammatory pathway, altering astrocyte phenotype, metabolism, and proliferation.

Original languageEnglish
Article number577455
JournalJournal of Neuroimmunology
Volume351
DOIs
StatePublished - 15 Feb 2021

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