TY - JOUR
T1 - Models of poststroke depression and assessments of core depressive symptoms in rodents
T2 - How to choose?
AU - Tao, Xi
AU - Yang, Wanlin
AU - Zhu, Shuzhen
AU - Que, Rongfang
AU - Liu, Chujuan
AU - Fan, Tao
AU - Wang, Jia
AU - Mo, Danheng
AU - Zhang, Zhuohua
AU - Tan, Jieqiong
AU - Jin, Kunlin
AU - Yenarih, Midori A.
AU - Song, Tao
AU - Wang, Qing
N1 - Funding Information:
This work was supported by the National Key R&D Program of China (No: 2017YFC1310200 ), Natural Science Foundations of Guangdong of China (Grant NO: 2017A030311010 ), Initiated Foundation of Zhujiang Hospital (No: 02020318005 ), Leading Talent in Talents Project Guangdong High-level Personnel of Special Support Program , and Scientific Research Foundation of Guangzhou (Grant NO: 201704030080 ) to Q.W., National Natural Science Foundation of China (Grant NO: 81801252 ) to XBW, and Nature Science Foundation of Hunan Province ( 2018JJ6104 , 2018JJ3295 ) and Science and Technology Planning Project of Changsha ( ZD1702033 ) to X.T. and J.W.
Publisher Copyright:
© 2019
PY - 2019/12
Y1 - 2019/12
N2 - Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are influenced by multiple factors such as disease history, education background, occupation, economic status, family relationships and social support. There are certain limitations to blood sample testing; for example, it is influenced by cerebrovascular diseases and some other disruptions of the internal environment. It is difficult for either method to fully clarify the pathophysiological mechanism of PSD. Animal models provide alternative methods to further understand the pathophysiological mechanisms of PSD, such as the involvement of neuronal circuits and cytokines. More than ten animal models of PSD have been developed, and new models are constantly being introduced. Therefore, it is important to choose the appropriate model for any given study. In this paper, we will discuss the characteristics of the different models of PSD and comment on the advantages and disadvantages of each model, drawing from research on model innovation. Finally, we briefly describe the current assessment methods for the core symptoms of PSD models, point out the shortcomings, and present the improved sucrose preference test as a rational evaluation of anhedonia.
AB - Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are influenced by multiple factors such as disease history, education background, occupation, economic status, family relationships and social support. There are certain limitations to blood sample testing; for example, it is influenced by cerebrovascular diseases and some other disruptions of the internal environment. It is difficult for either method to fully clarify the pathophysiological mechanism of PSD. Animal models provide alternative methods to further understand the pathophysiological mechanisms of PSD, such as the involvement of neuronal circuits and cytokines. More than ten animal models of PSD have been developed, and new models are constantly being introduced. Therefore, it is important to choose the appropriate model for any given study. In this paper, we will discuss the characteristics of the different models of PSD and comment on the advantages and disadvantages of each model, drawing from research on model innovation. Finally, we briefly describe the current assessment methods for the core symptoms of PSD models, point out the shortcomings, and present the improved sucrose preference test as a rational evaluation of anhedonia.
KW - Assessment
KW - Core symptom
KW - Model
KW - Post stroke depression
UR - http://www.scopus.com/inward/record.url?scp=85072050761&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2019.113060
DO - 10.1016/j.expneurol.2019.113060
M3 - Review article
C2 - 31505162
AN - SCOPUS:85072050761
SN - 0014-4886
VL - 322
JO - Experimental Neurology
JF - Experimental Neurology
M1 - 113060
ER -