Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?

Xi Tao, Wanlin Yang, Shuzhen Zhu, Rongfang Que, Chujuan Liu, Tao Fan, Jia Wang, Danheng Mo, Zhuohua Zhang, Jieqiong Tan, Kunlin Jin, Midori A. Yenarih, Tao Song, Qing Wang

Research output: Contribution to journalReview article

Abstract

Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are influenced by multiple factors such as disease history, education background, occupation, economic status, family relationships and social support. There are certain limitations to blood sample testing; for example, it is influenced by cerebrovascular diseases and some other disruptions of the internal environment. It is difficult for either method to fully clarify the pathophysiological mechanism of PSD. Animal models provide alternative methods to further understand the pathophysiological mechanisms of PSD, such as the involvement of neuronal circuits and cytokines. More than ten animal models of PSD have been developed, and new models are constantly being introduced. Therefore, it is important to choose the appropriate model for any given study. In this paper, we will discuss the characteristics of the different models of PSD and comment on the advantages and disadvantages of each model, drawing from research on model innovation. Finally, we briefly describe the current assessment methods for the core symptoms of PSD models, point out the shortcomings, and present the improved sucrose preference test as a rational evaluation of anhedonia.

Original languageEnglish
Article number113060
JournalExperimental Neurology
Volume322
DOIs
StatePublished - Dec 2019

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Rodentia
Stroke
Depression
Animal Models
Anhedonia
Cerebrovascular Disorders
Family Relations
Parkinsonian Disorders
Occupations
Research
Social Support
Neurodegenerative Diseases
Cognition
Blood Vessels
Parkinson Disease
Psychiatry
Sucrose
Economics
Cytokines
Morbidity

Keywords

  • Assessment
  • Core symptom
  • Model
  • Post stroke depression

Cite this

Tao, Xi ; Yang, Wanlin ; Zhu, Shuzhen ; Que, Rongfang ; Liu, Chujuan ; Fan, Tao ; Wang, Jia ; Mo, Danheng ; Zhang, Zhuohua ; Tan, Jieqiong ; Jin, Kunlin ; Yenarih, Midori A. ; Song, Tao ; Wang, Qing. / Models of poststroke depression and assessments of core depressive symptoms in rodents : How to choose?. In: Experimental Neurology. 2019 ; Vol. 322.
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title = "Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?",
abstract = "Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are influenced by multiple factors such as disease history, education background, occupation, economic status, family relationships and social support. There are certain limitations to blood sample testing; for example, it is influenced by cerebrovascular diseases and some other disruptions of the internal environment. It is difficult for either method to fully clarify the pathophysiological mechanism of PSD. Animal models provide alternative methods to further understand the pathophysiological mechanisms of PSD, such as the involvement of neuronal circuits and cytokines. More than ten animal models of PSD have been developed, and new models are constantly being introduced. Therefore, it is important to choose the appropriate model for any given study. In this paper, we will discuss the characteristics of the different models of PSD and comment on the advantages and disadvantages of each model, drawing from research on model innovation. Finally, we briefly describe the current assessment methods for the core symptoms of PSD models, point out the shortcomings, and present the improved sucrose preference test as a rational evaluation of anhedonia.",
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author = "Xi Tao and Wanlin Yang and Shuzhen Zhu and Rongfang Que and Chujuan Liu and Tao Fan and Jia Wang and Danheng Mo and Zhuohua Zhang and Jieqiong Tan and Kunlin Jin and Yenarih, {Midori A.} and Tao Song and Qing Wang",
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Tao, X, Yang, W, Zhu, S, Que, R, Liu, C, Fan, T, Wang, J, Mo, D, Zhang, Z, Tan, J, Jin, K, Yenarih, MA, Song, T & Wang, Q 2019, 'Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?', Experimental Neurology, vol. 322, 113060. https://doi.org/10.1016/j.expneurol.2019.113060

Models of poststroke depression and assessments of core depressive symptoms in rodents : How to choose? / Tao, Xi; Yang, Wanlin; Zhu, Shuzhen; Que, Rongfang; Liu, Chujuan; Fan, Tao; Wang, Jia; Mo, Danheng; Zhang, Zhuohua; Tan, Jieqiong; Jin, Kunlin; Yenarih, Midori A.; Song, Tao; Wang, Qing.

In: Experimental Neurology, Vol. 322, 113060, 12.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Models of poststroke depression and assessments of core depressive symptoms in rodents

T2 - How to choose?

AU - Tao, Xi

AU - Yang, Wanlin

AU - Zhu, Shuzhen

AU - Que, Rongfang

AU - Liu, Chujuan

AU - Fan, Tao

AU - Wang, Jia

AU - Mo, Danheng

AU - Zhang, Zhuohua

AU - Tan, Jieqiong

AU - Jin, Kunlin

AU - Yenarih, Midori A.

AU - Song, Tao

AU - Wang, Qing

PY - 2019/12

Y1 - 2019/12

N2 - Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are influenced by multiple factors such as disease history, education background, occupation, economic status, family relationships and social support. There are certain limitations to blood sample testing; for example, it is influenced by cerebrovascular diseases and some other disruptions of the internal environment. It is difficult for either method to fully clarify the pathophysiological mechanism of PSD. Animal models provide alternative methods to further understand the pathophysiological mechanisms of PSD, such as the involvement of neuronal circuits and cytokines. More than ten animal models of PSD have been developed, and new models are constantly being introduced. Therefore, it is important to choose the appropriate model for any given study. In this paper, we will discuss the characteristics of the different models of PSD and comment on the advantages and disadvantages of each model, drawing from research on model innovation. Finally, we briefly describe the current assessment methods for the core symptoms of PSD models, point out the shortcomings, and present the improved sucrose preference test as a rational evaluation of anhedonia.

AB - Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are influenced by multiple factors such as disease history, education background, occupation, economic status, family relationships and social support. There are certain limitations to blood sample testing; for example, it is influenced by cerebrovascular diseases and some other disruptions of the internal environment. It is difficult for either method to fully clarify the pathophysiological mechanism of PSD. Animal models provide alternative methods to further understand the pathophysiological mechanisms of PSD, such as the involvement of neuronal circuits and cytokines. More than ten animal models of PSD have been developed, and new models are constantly being introduced. Therefore, it is important to choose the appropriate model for any given study. In this paper, we will discuss the characteristics of the different models of PSD and comment on the advantages and disadvantages of each model, drawing from research on model innovation. Finally, we briefly describe the current assessment methods for the core symptoms of PSD models, point out the shortcomings, and present the improved sucrose preference test as a rational evaluation of anhedonia.

KW - Assessment

KW - Core symptom

KW - Model

KW - Post stroke depression

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U2 - 10.1016/j.expneurol.2019.113060

DO - 10.1016/j.expneurol.2019.113060

M3 - Review article

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AN - SCOPUS:85072050761

VL - 322

JO - Experimental Neurology

JF - Experimental Neurology

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