Mitochondrial mechanisms of estrogen neuroprotection

James W. Simpkins, Kun Don Yi, Shaohua Yang, James A. Dykens

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

Mitochondria have become a primary focus in our search not only for the mechanism(s) of neuronal death but also for neuroprotective drugs and therapies that can delay or prevent Alzheimer's disease and other chronic neurodegenerative conditions. This is because mitochrondria play a central role in regulating viability and death of neurons, and mitochondrial dysfunction has been shown to contribute to neuronal death seen in neurodegenerative diseases. In this article, we review the evidence for the role of mitochondria in cell death and neurodegeneration and provide evidence that estrogens have multiple effects on mitochondria that enhance or preserve mitochondrial function during pathologic circumstances such as excitotoxicity, oxidative stress, and others. As such, estrogens and novel non-hormonal analogs have come to figure prominently in our efforts to protect neurons against both acute brain injury and chronic neurodegeneration.

Original languageEnglish
Pages (from-to)1113-1120
Number of pages8
JournalBiochimica et Biophysica Acta - General Subjects
Volume1800
Issue number10
DOIs
StatePublished - 1 Oct 2010

Fingerprint

Mitochondria
Estrogens
Neurons
Neurodegenerative diseases
Oxidative stress
Neuroprotective Agents
Cell death
Neurodegenerative Diseases
Brain Injuries
Brain
Alzheimer Disease
Oxidative Stress
Cell Death
Drug Therapy
Neuroprotection

Keywords

  • Alzheimer's disease
  • Estradiol
  • Estrogen
  • Estrogen receptor
  • Mitochondria
  • Neuroprotection
  • Non-feminizing estrogens

Cite this

Simpkins, James W. ; Yi, Kun Don ; Yang, Shaohua ; Dykens, James A. / Mitochondrial mechanisms of estrogen neuroprotection. In: Biochimica et Biophysica Acta - General Subjects. 2010 ; Vol. 1800, No. 10. pp. 1113-1120.
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Mitochondrial mechanisms of estrogen neuroprotection. / Simpkins, James W.; Yi, Kun Don; Yang, Shaohua; Dykens, James A.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1800, No. 10, 01.10.2010, p. 1113-1120.

Research output: Contribution to journalReview article

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