Abstract
Mitochondrial transplantation/transfer has been increasingly recognized as a potential way for cell and tissue revitalization. In a recent study, Gabelein et al. reported a novel method for single cells mitochondria transplantation using “nanosyringe”. This technique combines atomic force microscopy, optical microscopy, and nanofluidics that enable intra- and intercellular organelle micromanipulation and cell-to-cell mitochondria transplantation with up to 95% success rate. The transferred mitochondria fuse to the host mitochondrial network and donor mtDNA incorporate into the recipient mitochondrial genome. The nanosyringe technique provides a novel tool for future mitochondrial research to offer insight into mitochondrial replacement therapy for stroke and fundamental mitochondrial biology.
Original language | English |
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Pages (from-to) | 1748-1750 |
Number of pages | 3 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 42 |
Issue number | 9 |
DOIs |
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State | Published - Sep 2022 |
Keywords
- Mitochondria
- mitochondrial transfer
- mitochondrial transplantation
- nanosyringe
- revitalization