Mitochondria transplantation/transfer between single cells

Qin Hu, Jianfei Lu, Xiaohua Zhang, Ran Liu, Shao Hua Yang

Research output: Contribution to journalComment/debate


Mitochondrial transplantation/transfer has been increasingly recognized as a potential way for cell and tissue revitalization. In a recent study, Gabelein et al. reported a novel method for single cells mitochondria transplantation using “nanosyringe”. This technique combines atomic force microscopy, optical microscopy, and nanofluidics that enable intra- and intercellular organelle micromanipulation and cell-to-cell mitochondria transplantation with up to 95% success rate. The transferred mitochondria fuse to the host mitochondrial network and donor mtDNA incorporate into the recipient mitochondrial genome. The nanosyringe technique provides a novel tool for future mitochondrial research to offer insight into mitochondrial replacement therapy for stroke and fundamental mitochondrial biology.

Original languageEnglish
Pages (from-to)1748-1750
Number of pages3
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number9
StatePublished - Sep 2022


  • Mitochondria
  • mitochondrial transfer
  • mitochondrial transplantation
  • nanosyringe
  • revitalization


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