MiR-9 promotes microglial activation by targeting MCPIP1

Honghong Yao, Rong Ma, Lu Yang, Guoku Hu, Xufeng Chen, Ming Duan, Yeonhee Kook, Fang Niu, Ke Liao, Minggui Fu, Gang Hu, Pappachan Kolattukudy, Shilpa Buch

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.

Original languageEnglish
Article number4386
JournalNature Communications
Volume5
DOIs
StatePublished - 14 Jul 2014

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Monocyte Chemoattractant Proteins
monocytes
MicroRNAs
Chemical activation
activation
proteins
Catenins
central nervous system
Proteins
Neurogenesis
Microglia
Neurology
Down-Regulation
Central Nervous System
Inflammation

Cite this

Yao, H., Ma, R., Yang, L., Hu, G., Chen, X., Duan, M., ... Buch, S. (2014). MiR-9 promotes microglial activation by targeting MCPIP1. Nature Communications, 5, [4386]. https://doi.org/10.1038/ncomms5386
Yao, Honghong ; Ma, Rong ; Yang, Lu ; Hu, Guoku ; Chen, Xufeng ; Duan, Ming ; Kook, Yeonhee ; Niu, Fang ; Liao, Ke ; Fu, Minggui ; Hu, Gang ; Kolattukudy, Pappachan ; Buch, Shilpa. / MiR-9 promotes microglial activation by targeting MCPIP1. In: Nature Communications. 2014 ; Vol. 5.
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abstract = "Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.",
author = "Honghong Yao and Rong Ma and Lu Yang and Guoku Hu and Xufeng Chen and Ming Duan and Yeonhee Kook and Fang Niu and Ke Liao and Minggui Fu and Gang Hu and Pappachan Kolattukudy and Shilpa Buch",
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Yao, H, Ma, R, Yang, L, Hu, G, Chen, X, Duan, M, Kook, Y, Niu, F, Liao, K, Fu, M, Hu, G, Kolattukudy, P & Buch, S 2014, 'MiR-9 promotes microglial activation by targeting MCPIP1', Nature Communications, vol. 5, 4386. https://doi.org/10.1038/ncomms5386

MiR-9 promotes microglial activation by targeting MCPIP1. / Yao, Honghong; Ma, Rong; Yang, Lu; Hu, Guoku; Chen, Xufeng; Duan, Ming; Kook, Yeonhee; Niu, Fang; Liao, Ke; Fu, Minggui; Hu, Gang; Kolattukudy, Pappachan; Buch, Shilpa.

In: Nature Communications, Vol. 5, 4386, 14.07.2014.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Yao, Honghong

AU - Ma, Rong

AU - Yang, Lu

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AU - Duan, Ming

AU - Kook, Yeonhee

AU - Niu, Fang

AU - Liao, Ke

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AU - Kolattukudy, Pappachan

AU - Buch, Shilpa

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AB - Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κ B pathway, but not the β 2-catenin pathway.

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