Metalloimmunoassay

Michael Cais; S. Dani; Y. Eden; O. Gandolfi; M. Horn; E. E. Isaacs; Y. Josephy; Y. Saar; E. Slovin; L. Snarsky

doi:10.1038/270534a0

Metalloimmunoassay

Michael Cais, S. Dani, Y. Eden, O. Gandolfi, M. Horn, E. E. Isaacs, Y. Josephy, Y. Saar, E. Slovin, L. Snarsky

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100 Scopus citations

Abstract

THE disadvantages encountered with radioisotopes, such as high costs, health hazards, limited variety of useable isotopes, short shelf-life of the labelled antigens and difficulties of introducing the radioactive isotope on to the antigen molecule, have stimulated the search for non-isotopic methods in immunological work¹. We report here on the feasibility of a novel non-isotopic system for immunochemical studies and its possible use in immunoassays. The basic concept of the new system is the use of metal atoms in the form of their organometallic or co-ordination complexes as labelling agents for haptens or macromolecular antigens.

Original language	English
Pages (from-to)	534-535
Number of pages	2
Journal	Nature
Volume	270
Issue number	5637
DOIs	https://doi.org/10.1038/270534a0
State	Published - 1977

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title = "Metalloimmunoassay",

abstract = "THE disadvantages encountered with radioisotopes, such as high costs, health hazards, limited variety of useable isotopes, short shelf-life of the labelled antigens and difficulties of introducing the radioactive isotope on to the antigen molecule, have stimulated the search for non-isotopic methods in immunological work1. We report here on the feasibility of a novel non-isotopic system for immunochemical studies and its possible use in immunoassays. The basic concept of the new system is the use of metal atoms in the form of their organometallic or co-ordination complexes as labelling agents for haptens or macromolecular antigens.",

author = "Michael Cais and S. Dani and Y. Eden and O. Gandolfi and M. Horn and Isaacs, {E. E.} and Y. Josephy and Y. Saar and E. Slovin and L. Snarsky",

year = "1977",

doi = "10.1038/270534a0",

language = "English",

volume = "270",

pages = "534--535",

journal = "Nature",

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TY - JOUR

T1 - Metalloimmunoassay

AU - Cais, Michael

AU - Dani, S.

AU - Eden, Y.

AU - Gandolfi, O.

AU - Horn, M.

AU - Isaacs, E. E.

AU - Josephy, Y.

AU - Saar, Y.

AU - Slovin, E.

AU - Snarsky, L.

PY - 1977

Y1 - 1977

N2 - THE disadvantages encountered with radioisotopes, such as high costs, health hazards, limited variety of useable isotopes, short shelf-life of the labelled antigens and difficulties of introducing the radioactive isotope on to the antigen molecule, have stimulated the search for non-isotopic methods in immunological work1. We report here on the feasibility of a novel non-isotopic system for immunochemical studies and its possible use in immunoassays. The basic concept of the new system is the use of metal atoms in the form of their organometallic or co-ordination complexes as labelling agents for haptens or macromolecular antigens.

AB - THE disadvantages encountered with radioisotopes, such as high costs, health hazards, limited variety of useable isotopes, short shelf-life of the labelled antigens and difficulties of introducing the radioactive isotope on to the antigen molecule, have stimulated the search for non-isotopic methods in immunological work1. We report here on the feasibility of a novel non-isotopic system for immunochemical studies and its possible use in immunoassays. The basic concept of the new system is the use of metal atoms in the form of their organometallic or co-ordination complexes as labelling agents for haptens or macromolecular antigens.

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DO - 10.1038/270534a0

M3 - Article

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AN - SCOPUS:0017770207

SN - 0028-0836

VL - 270

SP - 534

EP - 535

JO - Nature

JF - Nature

IS - 5637

ER -

Metalloimmunoassay

Abstract

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