Metal-enhanced fluorescence: Potential applications in HTS

Chris D. Geddes, Ignacy Gryczynski, Joanna Malicka, Zygmunt Gryczynski, Joseph R. Lakowicz

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalCombinatorial Chemistry and High Throughput Screening
Volume6
Issue number2
DOIs
StatePublished - Mar 2003

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