Metal-enhanced fluorescence: Potential applications in HTS

Chris D. Geddes, Ignacy Gryczynski, Joanna Malicka, Zygmunt Gryczynski, Joseph R. Lakowicz

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalCombinatorial Chemistry and High Throughput Screening
Issue number2
StatePublished - Mar 2003


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