Metal-enhanced fluorescence: An emerging tool in biotechnology

Kadir Aslan, Ignacy Gryczynski, Joanna Malicka, Evgenia Matveeva, Joseph R. Lakowicz, Chris D. Geddes

Research output: Contribution to journalReview articlepeer-review

593 Scopus citations

Abstract

Over the past 15 years, fluorescence has become the dominant detection/sensing technology in medical diagnostics and biotechnology. Although fluorescence is a highly sensitive technique, where single molecules can readily be detected, there is still a drive for reduced detection limits. The detection of a fluorophore is usually limited by its quantum yield, autofluorescence of the samples and/or the photostability of the fluorophores; however, there has been a recent explosion in the use of metallic nanostructures to favorably modify the spectral properties of fluorophores and to alleviate some of these fluorophore photophysical constraints. The use of fluorophore-metal interactions has been termed radiative decay engineering, metal-enhanced fluorescence or surface-enhanced fluorescence.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume16
Issue number1 SPEC. ISS.
DOIs
StatePublished - Feb 2005

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