Metal-enhanced emission from indocyanine green: A new approach to in vivo imaging

Joanna Malicka, Ignacy Gryczynski, Chris D. Geddes, Joseph R. Lakowicz

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Indocyanine green (ICC) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.

Original languageEnglish
Pages (from-to)472-478
Number of pages7
JournalJournal of Biomedical Optics
Volume8
Issue number3
DOIs
StatePublished - Jul 2003

Keywords

  • Idocyanine green
  • Metal-enhanced fluorescence
  • Silver islands

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