Metal-enhanced emission from indocyanine green: A new approach to in vivo imaging

Joanna Malicka; Ignacy Gryczynski; Chris D. Geddes; Joseph R. Lakowicz

doi:10.1117/1.1578643

Metal-enhanced emission from indocyanine green: A new approach to in vivo imaging

Joanna Malicka, Ignacy Gryczynski, Chris D. Geddes, Joseph R. Lakowicz

Microbiology, Immunology & Genetics

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Indocyanine green (ICC) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.

Original language	English
Pages (from-to)	472-478
Number of pages	7
Journal	Journal of Biomedical Optics
Volume	8
Issue number	3
DOIs	https://doi.org/10.1117/1.1578643
State	Published - Jul 2003

Keywords

Idocyanine green
Metal-enhanced fluorescence
Silver islands

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title = "Metal-enhanced emission from indocyanine green: A new approach to in vivo imaging",

abstract = "Indocyanine green (ICC) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.",

keywords = "Idocyanine green, Metal-enhanced fluorescence, Silver islands",

author = "Joanna Malicka and Ignacy Gryczynski and Geddes, {Chris D.} and Lakowicz, {Joseph R.}",

note = "Funding Information: This work was supported by the National Institutes of Health, National Center for Research Resources (grant RR-08119) and the National Cancer Institute (grant CA-100982).",

year = "2003",

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T1 - Metal-enhanced emission from indocyanine green

T2 - A new approach to in vivo imaging

AU - Malicka, Joanna

AU - Gryczynski, Ignacy

AU - Geddes, Chris D.

AU - Lakowicz, Joseph R.

N1 - Funding Information: This work was supported by the National Institutes of Health, National Center for Research Resources (grant RR-08119) and the National Cancer Institute (grant CA-100982).

PY - 2003/7

Y1 - 2003/7

N2 - Indocyanine green (ICC) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.

AB - Indocyanine green (ICC) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.

KW - Idocyanine green

KW - Metal-enhanced fluorescence

KW - Silver islands

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U2 - 10.1117/1.1578643

DO - 10.1117/1.1578643

M3 - Article

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EP - 478

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 3

ER -

Metal-enhanced emission from indocyanine green: A new approach to in vivo imaging

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Keywords

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