Metabolic protection of post-ischemic phosphorylation potential and ventricular performance

R. T. Mallet, R. Bunger, F. Prinzen, D. Allen, J. Bassingthwaighte

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Relationships between cytosolic phosphorylation potential, low-flow ischemic purine release and post-ischemic left ventricular developed pressure were examined in perfused working guinea-pig heart. During moderate ischemic acidification, metabolic intervention by pyruvate attenuated cytosolic NADH accumulation and (ATP+ADP+AMP) degradation. In reperfusion, spontaneously developed ventricular pressure increased in parallel with the phosphorylation potential (R2 = 0.71), but forced restoration of function by inotropic measures occurred at the expense of the phosphorylation potential.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalAdvances in experimental medicine and biology
Volume346
DOIs
StatePublished - 1993

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