TY - JOUR
T1 - Metabolic protection of post-ischemic phosphorylation potential and ventricular performance
AU - Mallet, R. T.
AU - Bunger, R.
AU - Prinzen, F.
AU - Allen, D.
AU - Bassingthwaighte, J.
PY - 1993
Y1 - 1993
N2 - Relationships between cytosolic phosphorylation potential, low-flow ischemic purine release and post-ischemic left ventricular developed pressure were examined in perfused working guinea-pig heart. During moderate ischemic acidification, metabolic intervention by pyruvate attenuated cytosolic NADH accumulation and (ATP+ADP+AMP) degradation. In reperfusion, spontaneously developed ventricular pressure increased in parallel with the phosphorylation potential (R2 = 0.71), but forced restoration of function by inotropic measures occurred at the expense of the phosphorylation potential.
AB - Relationships between cytosolic phosphorylation potential, low-flow ischemic purine release and post-ischemic left ventricular developed pressure were examined in perfused working guinea-pig heart. During moderate ischemic acidification, metabolic intervention by pyruvate attenuated cytosolic NADH accumulation and (ATP+ADP+AMP) degradation. In reperfusion, spontaneously developed ventricular pressure increased in parallel with the phosphorylation potential (R2 = 0.71), but forced restoration of function by inotropic measures occurred at the expense of the phosphorylation potential.
UR - http://www.scopus.com/inward/record.url?scp=0027753348&partnerID=8YFLogxK
U2 - 10.1007/978-1-4615-2946-0_22
DO - 10.1007/978-1-4615-2946-0_22
M3 - Article
C2 - 8184761
AN - SCOPUS:0027753348
SN - 0065-2598
VL - 346
SP - 233
EP - 241
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -