Abstract
Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 38-44 |
| Number of pages | 7 |
| Journal | Research Communications in Alcohol and Substances of Abuse |
| Volume | 22 |
| Issue number | 1-2 |
| State | Published - 1 Dec 2001 |
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Metabolic changes in the aging rat brain treated with alcohol and diazepam. / Mahammad, Riyaz B.; Shafeek, Abdul; Suresh, Ambati; Chetty, Chellu S.; Sajwan, Kenneth S.; Reddy, Gottipolu R.
In: Research Communications in Alcohol and Substances of Abuse, Vol. 22, No. 1-2, 01.12.2001, p. 38-44.Research output: Contribution to journal › Article
TY - JOUR
T1 - Metabolic changes in the aging rat brain treated with alcohol and diazepam
AU - Mahammad, Riyaz B.
AU - Shafeek, Abdul
AU - Suresh, Ambati
AU - Chetty, Chellu S.
AU - Sajwan, Kenneth S.
AU - Reddy, Gottipolu R.
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.
AB - Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.
UR - http://www.scopus.com/inward/record.url?scp=0038316710&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0038316710
VL - 22
SP - 38
EP - 44
JO - Research Communications in Alcohol and Substances of Abuse
JF - Research Communications in Alcohol and Substances of Abuse
SN - 1080-8388
IS - 1-2
ER -