Metabolic changes in the aging rat brain treated with alcohol and diazepam

Riyaz B. Mahammad, Abdul Shafeek, Ambati Suresh, Chellu S. Chetty, Kenneth S. Sajwan, Gottipolu R. Reddy

Research output: Contribution to journalArticlepeer-review

Abstract

Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalResearch Communications in Alcohol and Substances of Abuse
Volume22
Issue number1-2
StatePublished - 1 Dec 2001

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