Metabolic changes in the aging rat brain treated with alcohol and diazepam

Riyaz B. Mahammad; Abdul Shafeek; Ambati Suresh; Chellu S. Chetty; Kenneth S. Sajwan; Gottipolu R. Reddy

Metabolic changes in the aging rat brain treated with alcohol and diazepam

Riyaz B. Mahammad, Abdul Shafeek, Ambati Suresh, Chellu S. Chetty, Kenneth S. Sajwan, Gottipolu R. Reddy

Research output: Contribution to journal › Article › peer-review

Abstract

Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg²⁺ATPase and Na⁺-K⁺ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.

Original language	English
Pages (from-to)	38-44
Number of pages	7
Journal	Research Communications in Alcohol and Substances of Abuse
Volume	22
Issue number	1-2
State	Published - 1 Dec 2001

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title = "Metabolic changes in the aging rat brain treated with alcohol and diazepam",

abstract = "Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.",

author = "Mahammad, {Riyaz B.} and Abdul Shafeek and Ambati Suresh and Chetty, {Chellu S.} and Sajwan, {Kenneth S.} and Reddy, {Gottipolu R.}",

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T1 - Metabolic changes in the aging rat brain treated with alcohol and diazepam

AU - Mahammad, Riyaz B.

AU - Shafeek, Abdul

AU - Suresh, Ambati

AU - Chetty, Chellu S.

AU - Sajwan, Kenneth S.

AU - Reddy, Gottipolu R.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.

AB - Albino rats (Wistar) of two different age groups (3 months and 24 months) were treated with ethanol and/or diazepam for a period of five weeks. The cerebral cortex, striatum, hippocampus, and pons medulla were isolated from the brain for the assay of acetylcholinesterase (AChE), adenosine triphosphatases (ATPases) and acetylcholine (ACh). Both the individual and combined administration of ethanol or diazepam increased ACh levels in the tissues of the brain and decreased the specific activity of AChE, Mg2+ATPase and Na+-K+ATPase. The results indicated that combined administration of ethanol and diazepam exerted more pronounced alterations in these biochemical molecules and that the aging brain appears to be more susceptible to these drugs.

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