TY - JOUR
T1 - Mediation in the nucleus accumbens of the discriminative stimulus produced by cocaine
AU - Wood, Douglas M.
AU - Emmett-Oglesby, Michael W.
PY - 1989/6
Y1 - 1989/6
N2 - Rats were trained to detect an intraperitoneal (IP) administration of cocaine, 10.0 mg/kg, using a two-lever choice discrimination procedure in which food reinforcement was only delivered following 10 responses on the correct lever (FR10): one lever was correct after cocaine injection, and the other lever was correct after saline injection. Following training, cocaine was generalized to the cocaine training stimulus in a dose-dependent manner. Subsequently, guide cannulae were implanted bilaterally in the prefrontal cortex (from bregma, A = 2.7, L = 1.0, V = 3.0 mm), nucleus accumbens (A = 2.2, L = 1.5, V = 6 mm) or caudate putamen (A = 0.2, L = 2.5, V = 4). Injections were made via cannulae that extended 1 mm past the tip of the guide cannulae. Injection in the nucleus accumbens substituted for the IP training dose of cocaine in a dose-dependent manner with maximum generalization occuring with 10 μg of cocaine per side (87 % cocaine-lever responding); in contrast, injections of cocaine in the prefrontal cortex or caudate-putamen produced only partial cocaine-lever responding (a maximum of 48 and 37% cocaine-lever responding, respectively). These data support the hypothesis of central mediation of the cocaine stimulus and show that cocaine administered in the nucleus accumbens is sufficient to produce the stimulus. The partial substitution of cocaine in the prefrontal cortex and caudate-putamen may reflect partial mediation of the cocaine stimulus in these brain areas.
AB - Rats were trained to detect an intraperitoneal (IP) administration of cocaine, 10.0 mg/kg, using a two-lever choice discrimination procedure in which food reinforcement was only delivered following 10 responses on the correct lever (FR10): one lever was correct after cocaine injection, and the other lever was correct after saline injection. Following training, cocaine was generalized to the cocaine training stimulus in a dose-dependent manner. Subsequently, guide cannulae were implanted bilaterally in the prefrontal cortex (from bregma, A = 2.7, L = 1.0, V = 3.0 mm), nucleus accumbens (A = 2.2, L = 1.5, V = 6 mm) or caudate putamen (A = 0.2, L = 2.5, V = 4). Injections were made via cannulae that extended 1 mm past the tip of the guide cannulae. Injection in the nucleus accumbens substituted for the IP training dose of cocaine in a dose-dependent manner with maximum generalization occuring with 10 μg of cocaine per side (87 % cocaine-lever responding); in contrast, injections of cocaine in the prefrontal cortex or caudate-putamen produced only partial cocaine-lever responding (a maximum of 48 and 37% cocaine-lever responding, respectively). These data support the hypothesis of central mediation of the cocaine stimulus and show that cocaine administered in the nucleus accumbens is sufficient to produce the stimulus. The partial substitution of cocaine in the prefrontal cortex and caudate-putamen may reflect partial mediation of the cocaine stimulus in these brain areas.
KW - Cannula
KW - Caudate-putamen
KW - Cocaine
KW - Discrimination stimulus
KW - Medial prefrontal cortex
KW - Nucleus accumbens
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0024387397&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(89)90529-7
DO - 10.1016/0091-3057(89)90529-7
M3 - Article
C2 - 2813483
AN - SCOPUS:0024387397
SN - 0091-3057
VL - 33
SP - 453
EP - 457
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -