Mechanisms of Vasovagal Syncope: Relevance to Postflight Orthostatic Intolerance

Orthostatic intolerance can present a very serious limitation to astronauts attempting any junctions requiring the upright position. Vasovagal syncope is a common cause of fainting characterized by paradoxic bradycardia and vasodilation in the presence of decreasing arterial pressure. Several mechanisms have been proposed to mediate vasovagal syncope and it seems likely that redundant mechanisms exist both centrally and peripherally which can mediate these responses. Spaceflight alters reflex control of cardiovascular function in several ways which may influence susceptibility to vasovagal syncope provoked by the Bezold‐Jarisch reflex. 1994 American College of Clinical Pharmacology