Mechanisms of HIV-1 tat neurotoxicity via CDK5 translocation and hyper-activation: Role in HIV-associated neurocognitive disorders

Keyphrases

• Hyperactivity 100%
• HIV-1 Tat 100%
• Neurotoxicity 100%
• HIV-associated Neurocognitive Disorders 100%
• Cyclin-dependent Kinase 5 (Cdk5) 100%
• Mitochondrial Dysfunction 28%
• HyPer 28%
• CRMP2 28%
• Cell Survival 14%
• Signaling Pathway 14%
• Inflammatory Pathways 14%
• Oxidative Stress 14%
• Antiretroviral Therapy 14%
• Phosphorylation 14%
• Autophagy 14%
• Cell Death 14%
• Calpain 14%
• Novel Therapeutics 14%
• Neurogenesis 14%
• Angiogenesis 14%
• Cell Migration 14%
• Viral Glycoprotein 14%
• HIV-associated Dementia 14%
• Cell-to-cell 14%
• Neuronal Function 14%
• Doublecortin 14%
• Synaptic Plasticity 14%
• Gp120 14%
• Signal Transduction Pathway 14%
• Downstream Targets 14%
• Anti-neuroinflammation 14%
• Cytoskeletal Regulation 14%
• Neurodegenerative Mechanisms 14%
• Regulatory Subunit 14%
• Calcium Dysregulation 14%
• MEF2 14%
• Cell Cycle Re-entry 14%

Neuroscience

• Human Immunodeficiency Virus 100%
• Neurotoxicity 100%
• HIV Associated Dementia 100%
• Cell Signaling 40%
• Collapsin Response Mediator Protein 2 40%
• Autophagy 20%
• Calpain 1 20%
• Cell Death 20%
• Neurogenesis 20%
• Cell Survival 20%
• Cell Migration 20%
• Angiogenesis 20%
• Oxidative Stress 20%
• Doublecortin 20%
• Synaptic Plasticity 20%
• Excitotoxicity 20%
• Cell Cycle 20%
• Cyclin Dependent Kinase 5 20%

Pharmacology, Toxicology and Pharmaceutical Science

• HIV 100%
• Neurotoxicity 100%
• HIV Associated Dementia 100%
• Collapsin Response Mediator Protein 2 40%
• Calpain 1 20%
• Prevalence 20%
• Doublecortin 20%
• Excitotoxicity 20%
• Cyclin Dependent Kinase 5 20%
• Reentry Arrhythmia 20%