Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate

Abbot F. Clark

doi:10.1016/j.survophthal.2006.11.003

Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate

Abbot F. Clark

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Anecortave acetate is a unique angiostatic agent. Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity. These modifications have led to a new class of anti-angiogenic agents, the angiostatic cortisenes. Anecortave acetate has broad based angiostatic activity, inhibiting neovascularization at multiple steps. Unlike several other angiostatic agents that selectively target only one angiogenic factor, anecortave acetate inhibits neovascularization induced by many different angiogenic factors.

Original language	English
Pages (from-to)	S26-S34
Journal	Survey of Ophthalmology
Volume	52
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1016/j.survophthal.2006.11.003
State	Published - Jan 2007

Keywords

anecortave acetate, AL-3789
angiostatic agents
neovascularization
ocular angiogenesis

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10.1016/j.survophthal.2006.11.003

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abstract = "Anecortave acetate is a unique angiostatic agent. Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity. These modifications have led to a new class of anti-angiogenic agents, the angiostatic cortisenes. Anecortave acetate has broad based angiostatic activity, inhibiting neovascularization at multiple steps. Unlike several other angiostatic agents that selectively target only one angiogenic factor, anecortave acetate inhibits neovascularization induced by many different angiogenic factors.",

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AB - Anecortave acetate is a unique angiostatic agent. Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity. These modifications have led to a new class of anti-angiogenic agents, the angiostatic cortisenes. Anecortave acetate has broad based angiostatic activity, inhibiting neovascularization at multiple steps. Unlike several other angiostatic agents that selectively target only one angiogenic factor, anecortave acetate inhibits neovascularization induced by many different angiogenic factors.

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KW - ocular angiogenesis

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ER -

Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate

Abstract

Keywords

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