TY - JOUR
T1 - Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate
AU - Clark, Abbot
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Anecortave acetate is a unique angiostatic agent. Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity. These modifications have led to a new class of anti-angiogenic agents, the angiostatic cortisenes. Anecortave acetate has broad based angiostatic activity, inhibiting neovascularization at multiple steps. Unlike several other angiostatic agents that selectively target only one angiogenic factor, anecortave acetate inhibits neovascularization induced by many different angiogenic factors.
AB - Anecortave acetate is a unique angiostatic agent. Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity. These modifications have led to a new class of anti-angiogenic agents, the angiostatic cortisenes. Anecortave acetate has broad based angiostatic activity, inhibiting neovascularization at multiple steps. Unlike several other angiostatic agents that selectively target only one angiogenic factor, anecortave acetate inhibits neovascularization induced by many different angiogenic factors.
KW - anecortave acetate, AL-3789
KW - angiostatic agents
KW - neovascularization
KW - ocular angiogenesis
UR - http://www.scopus.com/inward/record.url?scp=33846198154&partnerID=8YFLogxK
U2 - 10.1016/j.survophthal.2006.11.003
DO - 10.1016/j.survophthal.2006.11.003
M3 - Article
C2 - 17240253
AN - SCOPUS:33846198154
VL - 52
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
SN - 0039-6257
IS - 1 SUPPL.
ER -