Mechanism of Action of the Angiostatic Cortisene Anecortave Acetate

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Abstract

Anecortave acetate is a unique angiostatic agent. Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity. These modifications have led to a new class of anti-angiogenic agents, the angiostatic cortisenes. Anecortave acetate has broad based angiostatic activity, inhibiting neovascularization at multiple steps. Unlike several other angiostatic agents that selectively target only one angiogenic factor, anecortave acetate inhibits neovascularization induced by many different angiogenic factors.

Original languageEnglish
JournalSurvey of Ophthalmology
Volume52
Issue number1 SUPPL.
DOIs
StatePublished - 1 Jan 2007

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Keywords

  • anecortave acetate, AL-3789
  • angiostatic agents
  • neovascularization
  • ocular angiogenesis

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