TY - JOUR
T1 - Maternal treatment with opioid analgesics and risk for birth defects
AU - Broussard, Cheryl S.
AU - Rasmussen, Sonja A.
AU - Reefhuis, Jennita
AU - Friedman, Jan M.
AU - Jann, Michael W.
AU - Riehle-Colarusso, Tiffany
AU - Honein, Margaret A.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011/4
Y1 - 2011/4
N2 - Objective: We examined whether maternal opioid treatment between 1 month before pregnancy and the first trimester was associated with birth defects. Study Design: The National Birth Defects Prevention Study (1997 through 2005) is an ongoing population-based case-control study. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIS) for birth defects categories with at least 200 case infants or at least 4 exposed case infants. Results: Therapeutic opioid use was reported by 2.6% of 17,449 case mothers and 2.0% of 6701 control mothers. Treatment was statistically significantly associated with conoventricular septal defects (OR, 2.7; 95% CI, 1.16.3), atrioventricular septal defects (OR, 2.0; 95% CI, 1.23.6), hypoplastic left heart syndrome (OR, 2.4; 95% CI, 1.44.1), spina bifida (OR, 2.0; 95% CI, 1.33.2), or gastroschisis (OR, 1.8; 95% CI, 1.12.9) in infants. Conclusion: Consistent with some previous investigations, our study shows an association between early pregnancy maternal opioid analgesic treatment and certain birth defects. This information should be considered by women and their physicians who are making treatment decisions during pregnancy.
AB - Objective: We examined whether maternal opioid treatment between 1 month before pregnancy and the first trimester was associated with birth defects. Study Design: The National Birth Defects Prevention Study (1997 through 2005) is an ongoing population-based case-control study. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIS) for birth defects categories with at least 200 case infants or at least 4 exposed case infants. Results: Therapeutic opioid use was reported by 2.6% of 17,449 case mothers and 2.0% of 6701 control mothers. Treatment was statistically significantly associated with conoventricular septal defects (OR, 2.7; 95% CI, 1.16.3), atrioventricular septal defects (OR, 2.0; 95% CI, 1.23.6), hypoplastic left heart syndrome (OR, 2.4; 95% CI, 1.44.1), spina bifida (OR, 2.0; 95% CI, 1.33.2), or gastroschisis (OR, 1.8; 95% CI, 1.12.9) in infants. Conclusion: Consistent with some previous investigations, our study shows an association between early pregnancy maternal opioid analgesic treatment and certain birth defects. This information should be considered by women and their physicians who are making treatment decisions during pregnancy.
KW - analgesic
KW - birth defect
KW - medication
KW - opioid
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=79953289743&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2010.12.039
DO - 10.1016/j.ajog.2010.12.039
M3 - Article
C2 - 21345403
AN - SCOPUS:79953289743
SN - 0002-9378
VL - 204
SP - 314.e1-314.e11
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 4
ER -