Abstract
A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.
Original language | English |
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Pages (from-to) | 279-282 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - 5 Jan 2004 |