Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Haiyin He, Bo Shen, Peter J. Petersen, William J. Weiss, Hui Y. Yang, Ting Zhong Wang, Russell G. Dushin, Frank E. Koehn, Guy T. Carter

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number1
DOIs
StatePublished - 5 Jan 2004

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    He, H., Shen, B., Petersen, P. J., Weiss, W. J., Yang, H. Y., Wang, T. Z., Dushin, R. G., Koehn, F. E., & Carter, G. T. (2004). Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 14(1), 279-282. https://doi.org/10.1016/j.bmcl.2003.09.071