Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Haiyin He; Bo Shen; Peter J. Petersen; William J. Weiss; Hui Y. Yang; Ting Zhong Wang; Russell G. Dushin; Frank E. Koehn; Guy T. Carter

doi:10.1016/j.bmcl.2003.09.071

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Haiyin He, Bo Shen, Peter J. Petersen, William J. Weiss, Hui Y. Yang, Ting Zhong Wang, Russell G. Dushin, Frank E. Koehn, Guy T. Carter

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.

Original language	English
Pages (from-to)	279-282
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2003.09.071
State	Published - 5 Jan 2004

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10.1016/j.bmcl.2003.09.071

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title = "Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria",

abstract = "A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.",

author = "Haiyin He and Bo Shen and Petersen, {Peter J.} and Weiss, {William J.} and Yang, {Hui Y.} and Wang, {Ting Zhong} and Dushin, {Russell G.} and Koehn, {Frank E.} and Carter, {Guy T.}",

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T1 - Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

AU - He, Haiyin

AU - Shen, Bo

AU - Petersen, Peter J.

AU - Weiss, William J.

AU - Yang, Hui Y.

AU - Wang, Ting Zhong

AU - Dushin, Russell G.

AU - Koehn, Frank E.

AU - Carter, Guy T.

PY - 2004/1/5

Y1 - 2004/1/5

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AB - A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.

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DO - 10.1016/j.bmcl.2003.09.071

M3 - Article

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AN - SCOPUS:0346887161

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EP - 282

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Abstract

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