Mannich Ketones as Possible Antimycobacterial Agents

Zsolt Lutz, Katalin Orbán, Ágnes Bóna, László Márk, Gábor Maász, Laszlo Prokai, Lázló Seress, Tamás Lóránd

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Twenty-three known unsaturated and fused Mannich ketones and their reduced derivatives (amino alcohols) were selected for an antituberculotic study. They were screened against several mycobacterial strains including Mycobacterium tuberculosis, M. xenopi, and M. gordonae, and minimum inhibitory concentration values were also determined using the standard antituberculotic drug isoniazid (INH) as a reference. Structure–activity relationships were also studied. The mode of action of the test compounds was investigated using transmission electron microscopy, high-performance liquid chromatography, and matrix-assisted desorption/ionization mass spectrometry. Several test substances proved to be as potent as INH, but their antimycobacterial spectra were broader than that of INH. Our findings suggest that their mode of action is probably through the inhibition of mycobacterial cell wall biosynthesis.

Original languageEnglish
Article number1700102
JournalArchiv der Pharmazie
Volume350
Issue number9
DOIs
StatePublished - 1 Sep 2017

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Gordonia Bacterium
Amino Alcohols
Isoniazid
Microbial Sensitivity Tests
Ketones
Transmission Electron Microscopy
Mycobacterium tuberculosis
Cell Wall
Mass Spectrometry
High Pressure Liquid Chromatography
Anti-Bacterial Agents
Pharmaceutical Preparations

Keywords

  • Antimycobacterial activity
  • Antituberculosis activity
  • Atypical mycobacteria

Cite this

Lutz, Z., Orbán, K., Bóna, Á., Márk, L., Maász, G., Prokai, L., ... Lóránd, T. (2017). Mannich Ketones as Possible Antimycobacterial Agents. Archiv der Pharmazie, 350(9), [1700102]. https://doi.org/10.1002/ardp.201700102
Lutz, Zsolt ; Orbán, Katalin ; Bóna, Ágnes ; Márk, László ; Maász, Gábor ; Prokai, Laszlo ; Seress, Lázló ; Lóránd, Tamás. / Mannich Ketones as Possible Antimycobacterial Agents. In: Archiv der Pharmazie. 2017 ; Vol. 350, No. 9.
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Lutz, Z, Orbán, K, Bóna, Á, Márk, L, Maász, G, Prokai, L, Seress, L & Lóránd, T 2017, 'Mannich Ketones as Possible Antimycobacterial Agents', Archiv der Pharmazie, vol. 350, no. 9, 1700102. https://doi.org/10.1002/ardp.201700102

Mannich Ketones as Possible Antimycobacterial Agents. / Lutz, Zsolt; Orbán, Katalin; Bóna, Ágnes; Márk, László; Maász, Gábor; Prokai, Laszlo; Seress, Lázló; Lóránd, Tamás.

In: Archiv der Pharmazie, Vol. 350, No. 9, 1700102, 01.09.2017.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lutz, Zsolt

AU - Orbán, Katalin

AU - Bóna, Ágnes

AU - Márk, László

AU - Maász, Gábor

AU - Prokai, Laszlo

AU - Seress, Lázló

AU - Lóránd, Tamás

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Lutz Z, Orbán K, Bóna Á, Márk L, Maász G, Prokai L et al. Mannich Ketones as Possible Antimycobacterial Agents. Archiv der Pharmazie. 2017 Sep 1;350(9). 1700102. https://doi.org/10.1002/ardp.201700102