Mannich Ketones as Possible Antimycobacterial Agents

Zsolt Lutz, Katalin Orbán, Ágnes Bóna, László Márk, Gábor Maász, László Prókai, Lázló Seress, Tamás Lóránd

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Twenty-three known unsaturated and fused Mannich ketones and their reduced derivatives (amino alcohols) were selected for an antituberculotic study. They were screened against several mycobacterial strains including Mycobacterium tuberculosis, M. xenopi, and M. gordonae, and minimum inhibitory concentration values were also determined using the standard antituberculotic drug isoniazid (INH) as a reference. Structure–activity relationships were also studied. The mode of action of the test compounds was investigated using transmission electron microscopy, high-performance liquid chromatography, and matrix-assisted desorption/ionization mass spectrometry. Several test substances proved to be as potent as INH, but their antimycobacterial spectra were broader than that of INH. Our findings suggest that their mode of action is probably through the inhibition of mycobacterial cell wall biosynthesis.

Original languageEnglish
Article number1700102
JournalArchiv der Pharmazie
Issue number9
StatePublished - Sep 2017


  • Antimycobacterial activity
  • Antituberculosis activity
  • Atypical mycobacteria


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