Management protocol for abacavir-related hypersensitivity reaction

Patrick G. Clay, R. Chris Rathbun, Leonard N. Slater

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


OBJECTIVE: To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center. DATA SYNTHESIS: Conference abstracts, published literature, and manufacturer- provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions. RESULTS: Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for CONCLUSIONS: Abacavir, newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalAnnals of Pharmacotherapy
Issue number2
StatePublished - 2000


  • Abacavir
  • Hypersensitivity


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