TY - JOUR
T1 - Magnesium intake and mortality due to liver diseases
T2 - Results from the Third National Health and Nutrition Examination Survey Cohort
AU - Wu, Lijun
AU - Zhu, Xiangzhu
AU - Fan, Lei
AU - Kabagambe, Edmond K.
AU - Song, Yiqing
AU - Tao, Menghua
AU - Zhong, Xiaosong
AU - Hou, Lifang
AU - Shrubsole, Martha J.
AU - Liu, Jie
AU - Dai, Qi
N1 - Funding Information:
X.Z. and Q.D. were partially supported by R01 CA202936 (to Q.D.) from the National Cancer Institute, Department of Health and Human Services.
Funding Information:
The efforts for Q.D. (Qi Dai) and X.Z. (Xiangzhu Zhu) were supported by NIH grants R01 CA202936 (to Q.D.). Q.D. was responsible for manuscript preparation and contributed to study design. L.W. contributed to the manuscript preparation. X.Z. is responsible for the data analysis and contributed to manuscript revision. L.F. (Lei Fan), E.K.K. (Edmond K. Kabagambe), Y.S. (Yiqing Song), M.T. (Menghua Tao), X.S.Z. (Xiaosong Zhong), L.H. (Lifang H), M.J.S. (Martha J. Shrubsole) and J.L. (Jie Liu) contributed to the data interpretation and manuscript revision. L.W., X.Z., L.F., E.K.K., Y.S., M.T., X.S.Z., L.H., M.J.S., J.L. and Q.D. approved the final version of this manuscript.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - People with fatty liver disease are at high risk of magnesium deficiency. Meanwhile, low magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between intake of magnesium and risk of mortality due to liver diseases. We evaluated the association between total magnesium intake and mortality due to liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall magnesium intake was associated with a reduced risk of mortality due to liver disease at borderline significance (P = 0.05). In fully-adjusted analyses, every 100 mg increase in intake of magnesium was associated with a 49% reduction in the risk for mortality due to liver diseases. Although interactions between magnesium intake and alcohol use and hepatic steatosis at baseline were not significant (P > 0.05), inverse associations between magnesium intake and liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our findings suggest higher intakes of magnesium may be associated with a reduced risk of mortality due to liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings.
AB - People with fatty liver disease are at high risk of magnesium deficiency. Meanwhile, low magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between intake of magnesium and risk of mortality due to liver diseases. We evaluated the association between total magnesium intake and mortality due to liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall magnesium intake was associated with a reduced risk of mortality due to liver disease at borderline significance (P = 0.05). In fully-adjusted analyses, every 100 mg increase in intake of magnesium was associated with a 49% reduction in the risk for mortality due to liver diseases. Although interactions between magnesium intake and alcohol use and hepatic steatosis at baseline were not significant (P > 0.05), inverse associations between magnesium intake and liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our findings suggest higher intakes of magnesium may be associated with a reduced risk of mortality due to liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings.
UR - http://www.scopus.com/inward/record.url?scp=85038637145&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-18076-5
DO - 10.1038/s41598-017-18076-5
M3 - Article
C2 - 29263344
AN - SCOPUS:85038637145
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 17913
ER -