TY - JOUR
T1 - Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release
AU - Tanaka, Satoshi
AU - Barron, Kirk W.
AU - Chandler, Margaret J.
AU - Linderoth, Bengt
AU - Foreman, Robert D.
N1 - Funding Information:
We thank Diana Holston (OUHSC) and Göte Hammarström (KI) for their expert technical assistance. This research was supported by NIH grant NS36775.
PY - 2001/3/30
Y1 - 2001/3/30
N2 - This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.
AB - This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.
KW - Antidromic afferent activation
KW - Calcitonin gene-related peptide
KW - Skin vasodilation
KW - Spinal cord stimulation
KW - Sympathetic inhibition
UR - http://www.scopus.com/inward/record.url?scp=0035970717&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(01)02144-8
DO - 10.1016/S0006-8993(01)02144-8
M3 - Article
C2 - 11277991
AN - SCOPUS:0035970717
VL - 896
SP - 183
EP - 187
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -