Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release

Satoshi Tanaka, Kirk W. Barron, Margaret J. Chandler, Bengt Linderoth, Robert D. Foreman

Research output: Contribution to journalArticle

50 Scopus citations


This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalBrain Research
Issue number1-2
Publication statusPublished - 30 Mar 2001



  • Antidromic afferent activation
  • Calcitonin gene-related peptide
  • Skin vasodilation
  • Spinal cord stimulation
  • Sympathetic inhibition

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