Abstract
This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.
| Original language | English |
|---|---|
| Pages (from-to) | 183-187 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 896 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 30 Mar 2001 |
Keywords
- Antidromic afferent activation
- Calcitonin gene-related peptide
- Skin vasodilation
- Spinal cord stimulation
- Sympathetic inhibition
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Tanaka, S., Barron, K. W., Chandler, M. J., Linderoth, B., & Foreman, R. D. (2001). Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release. Brain Research, 896(1-2), 183-187. https://doi.org/10.1016/S0006-8993(01)02144-8