Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release

Satoshi Tanaka; Kirk W. Barron; Margaret J. Chandler; Bengt Linderoth; Robert D. Foreman

doi:10.1016/S0006-8993(01)02144-8

Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release

Satoshi Tanaka, Kirk W. Barron, Margaret J. Chandler, Bengt Linderoth, Robert D. Foreman

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.

Original language	English
Pages (from-to)	183-187
Number of pages	5
Journal	Brain Research
Volume	896
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(01)02144-8
State	Published - 30 Mar 2001

Keywords

Antidromic afferent activation
Calcitonin gene-related peptide
Skin vasodilation
Spinal cord stimulation
Sympathetic inhibition

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10.1016/S0006-8993(01)02144-8

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title = "Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release",

abstract = "This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.",

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T1 - Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release

AU - Tanaka, Satoshi

AU - Barron, Kirk W.

AU - Chandler, Margaret J.

AU - Linderoth, Bengt

AU - Foreman, Robert D.

PY - 2001/3/30

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N2 - This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.

AB - This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8-37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.

KW - Antidromic afferent activation

KW - Calcitonin gene-related peptide

KW - Skin vasodilation

KW - Spinal cord stimulation

KW - Sympathetic inhibition

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JO - Brain Research

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SN - 0006-8993

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Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release

Abstract

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